Infantile spasms are an age-specific seizure disorder that occur in infants with no known underlying disorder or prior neurologic insult (cryptogenic group) as well as in infants with a variety of genetic disorders or known prior neurologic insult (symptomatic group). The presence of infantile spasms is associated with a high incidence of developmental retardation (87%) even in previously normal infants. Although there are many contradictory studies, it is generally believed that the infants in the symptomatic group, especially those with abnormal findings on neurologic examination prior to the onset of the seizures, have a significantly higher incidence of mental retardation and epilepsy than the infants in the cryptogenic group. We present three patients with infantile spasms secondary to unilateral nonhemorrhagic cerebral infarcts who showed significant clinical and electrophysiologic improvement following ACTH therapy.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1987|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health