Infantile spasms: A U.S. consensus report

John M. Pellock, Richard Hrachovy, Shlomo Shinnar, Tallie Z. Baram, David Bettis, Dennis J. Dlugos, William D. Gaillard, Patricia A. Gibson, Gregory L. Holmes, Douglas R. Nordli, Christine O'Dell, W. Donald Shields, Edwin Trevathan, James W. Wheless

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families-the Infantile Spasms Working Group (ISWG)-was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.

Original languageEnglish (US)
Pages (from-to)2175-2189
Number of pages15
JournalEpilepsia
Volume51
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Infantile Spasms
Consensus
Therapeutics
Physicians
Education
Continuity of Patient Care
Evidence-Based Practice
Practice Guidelines
Early Diagnosis
Electroencephalography

Keywords

  • Adrenocorticotropic hormone
  • Corticosteroids
  • Encephalopathic epilepsy
  • Infantile spasms
  • Treatment
  • Vigabatrin
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pellock, J. M., Hrachovy, R., Shinnar, S., Baram, T. Z., Bettis, D., Dlugos, D. J., ... Wheless, J. W. (2010). Infantile spasms: A U.S. consensus report. Epilepsia, 51(10), 2175-2189. https://doi.org/10.1111/j.1528-1167.2010.02657.x

Infantile spasms : A U.S. consensus report. / Pellock, John M.; Hrachovy, Richard; Shinnar, Shlomo; Baram, Tallie Z.; Bettis, David; Dlugos, Dennis J.; Gaillard, William D.; Gibson, Patricia A.; Holmes, Gregory L.; Nordli, Douglas R.; O'Dell, Christine; Shields, W. Donald; Trevathan, Edwin; Wheless, James W.

In: Epilepsia, Vol. 51, No. 10, 10.2010, p. 2175-2189.

Research output: Contribution to journalArticle

Pellock, JM, Hrachovy, R, Shinnar, S, Baram, TZ, Bettis, D, Dlugos, DJ, Gaillard, WD, Gibson, PA, Holmes, GL, Nordli, DR, O'Dell, C, Shields, WD, Trevathan, E & Wheless, JW 2010, 'Infantile spasms: A U.S. consensus report', Epilepsia, vol. 51, no. 10, pp. 2175-2189. https://doi.org/10.1111/j.1528-1167.2010.02657.x
Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ et al. Infantile spasms: A U.S. consensus report. Epilepsia. 2010 Oct;51(10):2175-2189. https://doi.org/10.1111/j.1528-1167.2010.02657.x
Pellock, John M. ; Hrachovy, Richard ; Shinnar, Shlomo ; Baram, Tallie Z. ; Bettis, David ; Dlugos, Dennis J. ; Gaillard, William D. ; Gibson, Patricia A. ; Holmes, Gregory L. ; Nordli, Douglas R. ; O'Dell, Christine ; Shields, W. Donald ; Trevathan, Edwin ; Wheless, James W. / Infantile spasms : A U.S. consensus report. In: Epilepsia. 2010 ; Vol. 51, No. 10. pp. 2175-2189.
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