Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens

R. A. Sidorov; E. G. Ugnivenko; E. M. Khovanova; G. A. Belitsky

doi:10.1016/S1383-5718(01)00277-7

Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens

R. A. Sidorov, E. G. Ugnivenko, E. M. Khovanova, G. A. Belitsky

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Ten chemicals were assessed for blastomogenic activity in adult wts/+ heterozygotes of D. melanogaster. All of the strong mammalian carcinogens tested (benzo(a)pyrene (B(a)P), pyrene, aflatoxin B₁, 2-acetylaminofluorene (2-AAF) and cis-dichlorodihydroxydiamminoplatinum IV) were also shown to be strong Drosophila blastomogens. They induced several times more tumors than their counterparts that are less carcinogenic for mammals (4-acetylaminofluorene (4-AAF), aflatoxins B₂ and G₂) and 4-(methylnitrosamino)-1-(-3-pyridine)-1-butanone (NNK). Benzo(e)pyrene (B(e)P) and pyrene demonstrated minor effects. Most tumors were localized on the wing and notum, which are the derivatives of the wing disc. Humeri derived from dorsal prothoracic disc and the abdominal tergites and sternites had the lowest number of tumors. The tumor frequency in the cross of the wild type females with wts^P2/TM6B males was different from that in the reciprocal cross. The former type of cross exhibited consistently higher tumor frequency both in the experimental and control series.

Original language	English (US)
Pages (from-to)	181-191
Number of pages	11
Journal	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume	498
Issue number	1-2
DOIs	https://doi.org/10.1016/S1383-5718(01)00277-7
State	Published - Nov 15 2001
Externally published	Yes

Keywords

Carcinogen
Drosophila
Somatic mosaicism
Tumor
Wts

ASJC Scopus subject areas

Genetics
Health, Toxicology and Mutagenesis

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10.1016/S1383-5718(01)00277-7

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title = "Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens",

abstract = "Ten chemicals were assessed for blastomogenic activity in adult wts/+ heterozygotes of D. melanogaster. All of the strong mammalian carcinogens tested (benzo(a)pyrene (B(a)P), pyrene, aflatoxin B1, 2-acetylaminofluorene (2-AAF) and cis-dichlorodihydroxydiamminoplatinum IV) were also shown to be strong Drosophila blastomogens. They induced several times more tumors than their counterparts that are less carcinogenic for mammals (4-acetylaminofluorene (4-AAF), aflatoxins B2 and G2) and 4-(methylnitrosamino)-1-(-3-pyridine)-1-butanone (NNK). Benzo(e)pyrene (B(e)P) and pyrene demonstrated minor effects. Most tumors were localized on the wing and notum, which are the derivatives of the wing disc. Humeri derived from dorsal prothoracic disc and the abdominal tergites and sternites had the lowest number of tumors. The tumor frequency in the cross of the wild type females with wtsP2/TM6B males was different from that in the reciprocal cross. The former type of cross exhibited consistently higher tumor frequency both in the experimental and control series.",

keywords = "Carcinogen, Drosophila, Somatic mosaicism, Tumor, Wts",

author = "Sidorov, {R. A.} and Ugnivenko, {E. G.} and Khovanova, {E. M.} and Belitsky, {G. A.}",

note = "Funding Information: This work was supported by the Russian Foundation for Basic Research, Grant no. 01-04-49285 and in part by International Science and Technology Centre, Grant no. U-832.",

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AU - Sidorov, R. A.

AU - Ugnivenko, E. G.

AU - Khovanova, E. M.

AU - Belitsky, G. A.

N1 - Funding Information: This work was supported by the Russian Foundation for Basic Research, Grant no. 01-04-49285 and in part by International Science and Technology Centre, Grant no. U-832.

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KW - Drosophila

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Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens

Abstract

Keywords

ASJC Scopus subject areas

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