Induction of the CXC chemokine interferon-γ-inducible protein 10 regulates the reparative response following myocardial infarction

Marcin Bujak, Marcin Dobaczewski, Carlos Gonzalez-Quesada, Ying Xia, Thorsten Leucker, Pawel Zymek, Vikas Veeranna, Andrew M. Tager, Andrew D. Luster, Nikolaos G. Frangogiannis

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Rationale: Interferon-γ-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with an important role in T-cell trafficking, is markedly induced in myocardial infarcts, and may regulate the reparative response. Objective: To study the role of IP-10 in cardiac repair and remodeling. Methods and Results: We studied cardiac repair in IP-10-null and wild-type (WT) mice undergoing reperfused infarction protocols and examined the effects of IP-10 on cardiac fibroblast function. IP-10-deficient and WT animals had comparable acute infarct size. However, the absence of IP-10 resulted in a hypercellular early reparative response and delayed contraction of the scar. Infarcted IP-10 -/- hearts exhibited accentuated early dilation, followed by rapid wall thinning during infarct maturation associated with systolic dysfunction. Although IP-10-null and WT mice had comparable cytokine expression, the absence of IP-10 was associated with marked alterations in the cellular content of the infarct. IP-10 -/- infarcts had more intense infiltration with CD45 + leukocytes, Mac-2 + macrophages, and α-smooth muscle actin (α-SMA) + myofibroblasts than WT infarcts but exhibited reduced recruitment of the subpopulations of leukocytes, T lymphocytes and α-SMA + cells that expressed CXCR3, the IP-10 receptor. IP-10 did not modulate cardiac fibroblast proliferation and apoptosis but significantly inhibited basic fibroblast growth factor-induced fibroblast migration. In addition, IP-10 enhanced growth factor-mediated wound contraction in fibroblast-populated collagen lattices. Conclusions: Endogenous IP-10 is an essential inhibitory signal that regulates the cellular composition of the healing infarct and promotes wound contraction, attenuating adverse remodeling. IP-10-mediated actions may be due, at least in part, to direct effects on fibroblast migration and function.

Original languageEnglish (US)
Pages (from-to)973-983
Number of pages11
JournalCirculation research
Issue number10
StatePublished - Nov 2009
Externally publishedYes


  • Chemokines
  • Fibrosis
  • Infarction
  • Remodeling
  • Wound healing

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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