Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis

Sourojit Bhowmick; Rachna Duseja; Sulagna Das; Mohan Babu Appaiahgiri; Sudhanshu Vrati; Anirban Basu

doi:10.1016/j.neulet.2006.11.070

Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis

Sourojit Bhowmick, Rachna Duseja, Sulagna Das, Mohan Babu Appaiahgiri, Sudhanshu Vrati, Anirban Basu

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-γ a known inducer of IP-10. However, this increase in IFN-γ level is not sufficient to confer protection as animals eventually succumb to the infection.

Original language	English (US)
Pages (from-to)	45-50
Number of pages	6
Journal	Neuroscience Letters
Volume	414
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2006.11.070
State	Published - Feb 27 2007
Externally published	Yes

Keywords

Astrocytes
IFN-γ
IP-10
Japanese encephalitis

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2006.11.070

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title = "Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis",

abstract = "Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-γ a known inducer of IP-10. However, this increase in IFN-γ level is not sufficient to confer protection as animals eventually succumb to the infection.",

keywords = "Astrocytes, IFN-γ, IP-10, Japanese encephalitis",

author = "Sourojit Bhowmick and Rachna Duseja and Sulagna Das and Appaiahgiri, {Mohan Babu} and Sudhanshu Vrati and Anirban Basu",

note = "Funding Information: This work was supported by grant (BT/PR/5799/MED/14/698/2005) from the Department of Biotechnology to A.B. We thank Director, NBRC for her support and encouragement.",

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AU - Bhowmick, Sourojit

AU - Duseja, Rachna

AU - Das, Sulagna

AU - Appaiahgiri, Mohan Babu

AU - Vrati, Sudhanshu

AU - Basu, Anirban

N1 - Funding Information: This work was supported by grant (BT/PR/5799/MED/14/698/2005) from the Department of Biotechnology to A.B. We thank Director, NBRC for her support and encouragement.

PY - 2007/2/27

Y1 - 2007/2/27

N2 - Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-γ a known inducer of IP-10. However, this increase in IFN-γ level is not sufficient to confer protection as animals eventually succumb to the infection.

AB - Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-γ a known inducer of IP-10. However, this increase in IFN-γ level is not sufficient to confer protection as animals eventually succumb to the infection.

KW - Astrocytes

KW - IFN-γ

KW - IP-10

KW - Japanese encephalitis

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Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis

Abstract

Keywords

ASJC Scopus subject areas

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