Induction of G2M arrest by flavokawain a, a kava chalcone, increases the responsiveness of HER2-overexpressing breast cancer cells to herceptin

Medicine & Life Sciences

• flavokawain A 100%
• Kava 75%
• Chalcone 70%
• Trastuzumab 55%
• Breast Neoplasms 29%
• Survivin 15%
• Cell Line 15%
• Down-Regulation 14%
• Phosphorylation 9%
• Apoptosis 8%
• Growth 6%
• Cell Cycle Checkpoints 6%
• Phosphotransferases 5%
• Breast 5%
• Proteins 4%
• Epithelial Cells 4%
• Mortality 3%

Physics & Astronomy

• breast 49%
• cancer 43%
• induction 42%
• cultured cells 27%
• phosphorylation 16%
• apoptosis 16%
• multiple docking adapters 9%
• proteins 9%
• mortality 8%
• progressions 6%
• viability 6%
• cells 6%
• tumors 5%
• cycles 3%

Chemical Compounds

• Chalcone 54%
• Apoptosis Inducer 37%
• Blocking Agent 31%
• Protein 19%