Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: Effect of chemical structure and stress signals

Medicine & Life Sciences

• diallyl trisulfide 100%
• NF-E2-Related Factor 2 83%
• Garlic 76%
• Enzyme Induction 75%
• Antioxidant Response Elements 74%
• Transcription Factors 44%
• Hep G2 Cells 15%
• Protein Kinase Inhibitors 15%
• Mitogen-Activated Protein Kinases 14%
• Proteins 13%
• diallyl disulfide 12%
• Enzymes 12%
• allyl sulfide 11%
• Antioxidants 10%
• quinone 8%
• Calcium Signaling 8%
• Sulfur 8%
• Heme Oxygenase-1 8%
• Structure-Activity Relationship 8%
• JNK Mitogen-Activated Protein Kinases 8%
• Extracellular Signal-Regulated MAP Kinases 7%
• Sulfhydryl Compounds 7%
• NAD 7%
• Reporter Genes 7%
• Protein Kinase C 6%
• Protein Kinases 6%
• Oxidoreductases 6%
• Transfection 6%
• Hepatocellular Carcinoma 5%
• Up-Regulation 5%
• Gene Expression 4%
• Pharmaceutical Preparations 3%

Chemical Compounds

• Organosulfur Compound 80%
• Diallyl Trisulfide 46%
• Antioxidant Agent 44%
• Protein 24%
• Protein Kinase Inhibitor 19%
• Diallyl Sulfide 11%
• Diallyl Disulfide 10%
• Chemopreventive 9%
• Cytoprotective 9%
• NAD(P)H 8%
• Inductive Effect 7%
• Quinone 6%
• Structure-Activity Relationship 5%
• Thiol 5%
• Pharmacological Metabolism 5%
• Bioactivity 4%
• Drug 3%