Induction of depression with oxotremorine in patients with Alzheimer's disease

K. L. Davis, E. Hollander, M. Davidson, R. C. Mohs, T. B. Horvath

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effect on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of these side effects. Cardiovascular effects of the drug were negligible, but its effect on memory and cognition remains unknown because of the small number of subjects who completed the study.

Original languageEnglish (US)
Pages (from-to)468-471
Number of pages4
JournalAmerican Journal of Psychiatry
Volume144
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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