Abstract
Sixty-seven subjects, including normal volunteers and patients with obsessive-compulsive disorder, social phobia, and borderline personality disorder, received ratings of depersonalization after double-blind, placebo-controlled challenges with the partial serotonin agonist meta-chlorophenylpiperazine (m-CPP). Challenge with m-CPP induced depersonalization significantly more than did placebo. Subjects who became depersonalized did not differ in age, sex, or diagnosis from those who did not experience depersonalization. There was a significant correlation between the induction of depersonalization and increase in panic, but not nervousness, anxiety, sadness, depression, or drowsiness. This report suggests that serotonergic dysregulation may in part underlie depersonalization.
Original language | English (US) |
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Pages (from-to) | 161-164 |
Number of pages | 4 |
Journal | Psychiatry Research |
Volume | 58 |
Issue number | 2 |
DOIs | |
State | Published - Sep 29 1995 |
Externally published | Yes |
Keywords
- Borderline personality disorder
- Obsessive-compulsive disorder
- Panic
- Social phobia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry