Abstract
Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-420 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 176 |
| Issue number | 4030 |
| State | Published - 1972 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
Cite this
Induction of benzo[α]pyrene hydroxylase in human skin. / Levin, W.; Conney, A. H.; Alvares, A. P.; Merkatz, Irwin R.; Kappas, A.
In: Science, Vol. 176, No. 4030, 1972, p. 419-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of benzo[α]pyrene hydroxylase in human skin
AU - Levin, W.
AU - Conney, A. H.
AU - Alvares, A. P.
AU - Merkatz, Irwin R.
AU - Kappas, A.
PY - 1972
Y1 - 1972
N2 - Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
AB - Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
UR - http://www.scopus.com/inward/record.url?scp=0015526857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015526857&partnerID=8YFLogxK
M3 - Article
C2 - 4402068
AN - SCOPUS:0015526857
VL - 176
SP - 419
EP - 420
JO - Science
JF - Science
SN - 0036-8075
IS - 4030
ER -