Induction of benzo[α]pyrene hydroxylase in human skin

W. Levin, A. H. Conney, A. P. Alvares, Irwin R. Merkatz, A. Kappas

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.

Original languageEnglish (US)
Pages (from-to)419-420
Number of pages2
JournalScience
Volume176
Issue number4030
StatePublished - 1972
Externally publishedYes

Fingerprint

Mixed Function Oxygenases
Carcinogens
Foreskin
Skin
Enzymes
Parturition
pyrene

ASJC Scopus subject areas

  • General

Cite this

Levin, W., Conney, A. H., Alvares, A. P., Merkatz, I. R., & Kappas, A. (1972). Induction of benzo[α]pyrene hydroxylase in human skin. Science, 176(4030), 419-420.

Induction of benzo[α]pyrene hydroxylase in human skin. / Levin, W.; Conney, A. H.; Alvares, A. P.; Merkatz, Irwin R.; Kappas, A.

In: Science, Vol. 176, No. 4030, 1972, p. 419-420.

Research output: Contribution to journalArticle

Levin, W, Conney, AH, Alvares, AP, Merkatz, IR & Kappas, A 1972, 'Induction of benzo[α]pyrene hydroxylase in human skin', Science, vol. 176, no. 4030, pp. 419-420.
Levin W, Conney AH, Alvares AP, Merkatz IR, Kappas A. Induction of benzo[α]pyrene hydroxylase in human skin. Science. 1972;176(4030):419-420.
Levin, W. ; Conney, A. H. ; Alvares, A. P. ; Merkatz, Irwin R. ; Kappas, A. / Induction of benzo[α]pyrene hydroxylase in human skin. In: Science. 1972 ; Vol. 176, No. 4030. pp. 419-420.
@article{f4d039cbca0e4250be8a4f017f8a4eb3,
title = "Induction of benzo[α]pyrene hydroxylase in human skin",
abstract = "Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.",
author = "W. Levin and Conney, {A. H.} and Alvares, {A. P.} and Merkatz, {Irwin R.} and A. Kappas",
year = "1972",
language = "English (US)",
volume = "176",
pages = "419--420",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4030",

}

TY - JOUR

T1 - Induction of benzo[α]pyrene hydroxylase in human skin

AU - Levin, W.

AU - Conney, A. H.

AU - Alvares, A. P.

AU - Merkatz, Irwin R.

AU - Kappas, A.

PY - 1972

Y1 - 1972

N2 - Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.

AB - Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.

UR - http://www.scopus.com/inward/record.url?scp=0015526857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015526857&partnerID=8YFLogxK

M3 - Article

C2 - 4402068

AN - SCOPUS:0015526857

VL - 176

SP - 419

EP - 420

JO - Science

JF - Science

SN - 0036-8075

IS - 4030

ER -