Induction of benzo[α]pyrene hydroxylase in human skin

W. Levin; A. H. Conney; A. P. Alvares; I. Merkatz; A. Kappas

doi:10.1126/science.176.4033.419

Induction of benzo[α]pyrene hydroxylase in human skin

W. Levin, A. H. Conney, A. P. Alvares, I. Merkatz, A. Kappas

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.

Original language	English (US)
Pages (from-to)	419-420
Number of pages	2
Journal	Science
Volume	176
Issue number	4030
DOIs	https://doi.org/10.1126/science.176.4033.419
State	Published - 1972
Externally published	Yes

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abstract = "Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.",

author = "W. Levin and Conney, {A. H.} and Alvares, {A. P.} and I. Merkatz and A. Kappas",

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AU - Conney, A. H.

AU - Alvares, A. P.

AU - Merkatz, I.

AU - Kappas, A.

PY - 1972

Y1 - 1972

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AB - Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.

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Induction of benzo[α]pyrene hydroxylase in human skin

Abstract

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