Abstract
Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
Original language | English (US) |
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Pages (from-to) | 419-420 |
Number of pages | 2 |
Journal | Science |
Volume | 176 |
Issue number | 4030 |
DOIs | |
State | Published - 1972 |
Externally published | Yes |
ASJC Scopus subject areas
- General