Induction of autoreactive B cells allows priming of autoreactive T cells

Rong Hwa Lin, Mark J. Mamula, John A. Hardin, Charles A. Janeway

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.

Original languageEnglish (US)
Pages (from-to)1433-1439
Number of pages7
JournalJournal of Experimental Medicine
Volume173
Issue number6
StatePublished - Jun 1 1991
Externally publishedYes

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Self Tolerance
B-Lymphocytes
T-Lymphocytes
Cytochromes c
Autoantibodies
Antigens
Immunization
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Lin, R. H., Mamula, M. J., Hardin, J. A., & Janeway, C. A. (1991). Induction of autoreactive B cells allows priming of autoreactive T cells. Journal of Experimental Medicine, 173(6), 1433-1439.

Induction of autoreactive B cells allows priming of autoreactive T cells. / Lin, Rong Hwa; Mamula, Mark J.; Hardin, John A.; Janeway, Charles A.

In: Journal of Experimental Medicine, Vol. 173, No. 6, 01.06.1991, p. 1433-1439.

Research output: Contribution to journalArticle

Lin, RH, Mamula, MJ, Hardin, JA & Janeway, CA 1991, 'Induction of autoreactive B cells allows priming of autoreactive T cells', Journal of Experimental Medicine, vol. 173, no. 6, pp. 1433-1439.
Lin RH, Mamula MJ, Hardin JA, Janeway CA. Induction of autoreactive B cells allows priming of autoreactive T cells. Journal of Experimental Medicine. 1991 Jun 1;173(6):1433-1439.
Lin, Rong Hwa ; Mamula, Mark J. ; Hardin, John A. ; Janeway, Charles A. / Induction of autoreactive B cells allows priming of autoreactive T cells. In: Journal of Experimental Medicine. 1991 ; Vol. 173, No. 6. pp. 1433-1439.
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