Induction of autoreactive B cells allows priming of autoreactive T cells

Rong Hwa Lin, Mark J. Mamula, John A. Hardin, Charles A. Janeway

Research output: Contribution to journalArticle

222 Scopus citations


A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.

Original languageEnglish (US)
Pages (from-to)1433-1439
Number of pages7
JournalJournal of Experimental Medicine
Issue number6
StatePublished - Jun 1 1991


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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