Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

Jennifer A. Cummings; Saleem M. Nicola; Robert C. Malenka

doi:10.1016/0304-3940(94)90883-4

Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

Jennifer A. Cummings, Saleem M. Nicola, Robert C. Malenka

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77 Scopus citations

Abstract

Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor l-N^G-nitroarginine (NOArg) (100 μM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 μM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

Original language	English (US)
Pages (from-to)	110-114
Number of pages	5
Journal	Neuroscience Letters
Volume	176
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90883-4
State	Published - Jul 18 1994
Externally published	Yes

Keywords

CA1
Hippocampus
Long-term depression
Long-term potentiation
Nitric oxide
l-N-nitroarginine

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90883-4

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title = "Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor",

abstract = "Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor l-NG-nitroarginine (NOArg) (100 μM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 μM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.",

keywords = "CA1, Hippocampus, Long-term depression, Long-term potentiation, Nitric oxide, l-N-nitroarginine",

author = "Cummings, {Jennifer A.} and Nicola, {Saleem M.} and Malenka, {Robert C.}",

note = "Funding Information: We thank David Bredt and Roger Nicoll for helpful discussions and critical reading of the manuscript. This work was supported by grants from the National Institute of Mental Health, the McKnight Endowment Fund for Neuroscience, and the National Alliance for Research on Schizophrenia and Depression (to R.C.M.). J.A.C. is supported by a Howard Hughes Medical Institute predoctoral fellowship, and S.M.N. is supported by a predoctoral fellowship from the NIMH.",

year = "1994",

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doi = "10.1016/0304-3940(94)90883-4",

language = "English (US)",

volume = "176",

pages = "110--114",

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T1 - Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

AU - Cummings, Jennifer A.

AU - Nicola, Saleem M.

AU - Malenka, Robert C.

N1 - Funding Information: We thank David Bredt and Roger Nicoll for helpful discussions and critical reading of the manuscript. This work was supported by grants from the National Institute of Mental Health, the McKnight Endowment Fund for Neuroscience, and the National Alliance for Research on Schizophrenia and Depression (to R.C.M.). J.A.C. is supported by a Howard Hughes Medical Institute predoctoral fellowship, and S.M.N. is supported by a predoctoral fellowship from the NIMH.

PY - 1994/7/18

Y1 - 1994/7/18

N2 - Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor l-NG-nitroarginine (NOArg) (100 μM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 μM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

AB - Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor l-NG-nitroarginine (NOArg) (100 μM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 μM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

KW - CA1

KW - Hippocampus

KW - Long-term depression

KW - Long-term potentiation

KW - Nitric oxide

KW - l-N-nitroarginine

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JO - Neuroscience Letters

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IS - 1

ER -

Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

Abstract

Keywords

ASJC Scopus subject areas

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