Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

Jennifer A. Cummings, Saleem M. Nicola, Robert C. Malenka

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor l-NG-nitroarginine (NOArg) (100 μM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 μM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalNeuroscience Letters
Volume176
Issue number1
DOIs
StatePublished - Jul 18 1994
Externally publishedYes

Keywords

  • CA1
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Nitric oxide
  • l-N-nitroarginine

ASJC Scopus subject areas

  • Neuroscience(all)

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