Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen

Dimitrijević Mirjana, Laban Olgica, Stanojević Stanislava, Radulović Jelena

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalActa Veterinaria
Volume50
Issue number5-6
StatePublished - 2000
Externally publishedYes

Keywords

  • Anti-myelin basic protein antibodies
  • DA rats
  • Experimental allergic encephalomyelitis

ASJC Scopus subject areas

  • veterinary(all)

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