Abstract
Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-296 |
| Number of pages | 8 |
| Journal | Acta Veterinaria |
| Volume | 50 |
| Issue number | 5-6 |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Anti-myelin basic protein antibodies
- DA rats
- Experimental allergic encephalomyelitis
ASJC Scopus subject areas
- General Veterinary