Indomethacin: lack of effect on lethality of endotoxin in rats

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Abstract

The effect of indomethacin on lethality of endotoxin in lead acetate sensitized rats was studied. Rats (334 ± 4 g, n=26) received intravenous injections of endotoxin in lead acetate (5 mg/ml) 0.9% saline. The LD50 of endotoxin was 0.075 mg/kg. Lead acetate caused no mortality at 24 hours. Similar doses of endotoxin in lead acetate were injected intravenously and 12% ethanol (0.6 M phosphate buffer, pH 8.0) administered by gavage to 39 animals. The LD50 was 0.064 mg/kg (not significant). An additional 40 animals received indomethacin (10 mg/kg) in alcohol buffer immediately before injection of endotoxin lead acetate. The LD50 was 0.051 mg/kg (not significant). Indomethacin alone (10 animals) caused no mortality. The dose of indomethacin was sufficient to inhibit prostaglandin synthesis effectively for the 24 hour observation period. Indomethacin does not alter endotoxin caused mortality in lead acetate sensitized rats.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalCirculatory Shock
Volume2
Issue number3
StatePublished - 1975
Externally publishedYes

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Endotoxins
Indomethacin
Lethal Dose 50
Mortality
Buffers
Intravenous Injections
Prostaglandins
lead acetate
Ethanol
Phosphates
Alcohols
Observation
Injections

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Indomethacin : lack of effect on lethality of endotoxin in rats. / Reichgott, Michael J.; Engelman, K.

In: Circulatory Shock, Vol. 2, No. 3, 1975, p. 215-219.

Research output: Contribution to journalArticle

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