Individuals with exceptional longevity manifest a delayed association between vitamin d insufficiency and cognitive impairment

Sofiya Milman, Micol Schulder-Katz, Jennifer Deluty, Molly E. Zimmerman, Jill P. Crandall, Nir Barzilai, Michal L. Melamed, Gil Atzmon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives To define vitamin D levels and their association with cognition in subjects with exceptional longevity. Design Cross-sectional. Setting Community and long-term care facilities. Participants Ashkenazi Jewish subjects (n = 253) with exceptional longevity, with comparison made to the Third National Health and Nutrition Examination Survey (NHANES III) participants aged 70 and older. Measurements Serum 25-hydroxyvitamin D levels were measured using liquid chromatography/tandem mass spectrometry analysis. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and clock drawing test (CDT: command and copy). Results The median age of the Ashkenazi subjects was 97 (interquartile range (IQR) 95-104). Age-associated rise in the prevalence of vitamin D insufficiency, defined as a serum vitamin D level of less than 30 ng/mL, was noted in NHANES III (P =.001). In the Ashkenazi group with longevity, the rate of vitamin D insufficiency was comparable with that of the NHANES III participants, who were up to 25 years younger. In the cohort with exceptional longevity, 49% demonstrated cognitive impairment as assessed according to MMSE score (impaired cognition, median 9.5 IQR 0-24); normal cognition, median 29 (IQR 18-30) P <.001). Vitamin D insufficiency was more prevalent in those with impaired cognition, defined according to the MMSE (71.8% vs 57.7%, P =.02) and the CDT copy (84.6% vs. 50.6%, P =.02), than in those with normal cognition. This association remained significant after multivariable adjustment in logistic regression models for cognitive assessments made using the MMSE (odds ratio (OR) = 3.2, 95% confidence interval (CI) = 1.1-9.29, P =.03) and the CDT copy (OR = 8.96, 95% CI = 1.08-74.69, P =.04). Conclusion Higher vitamin D levels may be a marker of delayed aging, because they are associated with better cognitive function in people achieving exceptional longevity.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalJournal of the American Geriatrics Society
Volume62
Issue number1
DOIs
StatePublished - Jan 2014

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Vitamins
Cognition
Vitamin D
Nutrition Surveys
Logistic Models
Odds Ratio
Confidence Intervals
Social Adjustment
Long-Term Care
Tandem Mass Spectrometry
Cognitive Dysfunction
Serum
Liquid Chromatography

Keywords

  • cognitive function
  • exceptional longevity
  • vitamin D

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Individuals with exceptional longevity manifest a delayed association between vitamin d insufficiency and cognitive impairment. / Milman, Sofiya; Schulder-Katz, Micol; Deluty, Jennifer; Zimmerman, Molly E.; Crandall, Jill P.; Barzilai, Nir; Melamed, Michal L.; Atzmon, Gil.

In: Journal of the American Geriatrics Society, Vol. 62, No. 1, 01.2014, p. 153-158.

Research output: Contribution to journalArticle

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title = "Individuals with exceptional longevity manifest a delayed association between vitamin d insufficiency and cognitive impairment",
abstract = "Objectives To define vitamin D levels and their association with cognition in subjects with exceptional longevity. Design Cross-sectional. Setting Community and long-term care facilities. Participants Ashkenazi Jewish subjects (n = 253) with exceptional longevity, with comparison made to the Third National Health and Nutrition Examination Survey (NHANES III) participants aged 70 and older. Measurements Serum 25-hydroxyvitamin D levels were measured using liquid chromatography/tandem mass spectrometry analysis. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and clock drawing test (CDT: command and copy). Results The median age of the Ashkenazi subjects was 97 (interquartile range (IQR) 95-104). Age-associated rise in the prevalence of vitamin D insufficiency, defined as a serum vitamin D level of less than 30 ng/mL, was noted in NHANES III (P =.001). In the Ashkenazi group with longevity, the rate of vitamin D insufficiency was comparable with that of the NHANES III participants, who were up to 25 years younger. In the cohort with exceptional longevity, 49{\%} demonstrated cognitive impairment as assessed according to MMSE score (impaired cognition, median 9.5 IQR 0-24); normal cognition, median 29 (IQR 18-30) P <.001). Vitamin D insufficiency was more prevalent in those with impaired cognition, defined according to the MMSE (71.8{\%} vs 57.7{\%}, P =.02) and the CDT copy (84.6{\%} vs. 50.6{\%}, P =.02), than in those with normal cognition. This association remained significant after multivariable adjustment in logistic regression models for cognitive assessments made using the MMSE (odds ratio (OR) = 3.2, 95{\%} confidence interval (CI) = 1.1-9.29, P =.03) and the CDT copy (OR = 8.96, 95{\%} CI = 1.08-74.69, P =.04). Conclusion Higher vitamin D levels may be a marker of delayed aging, because they are associated with better cognitive function in people achieving exceptional longevity.",
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T1 - Individuals with exceptional longevity manifest a delayed association between vitamin d insufficiency and cognitive impairment

AU - Milman, Sofiya

AU - Schulder-Katz, Micol

AU - Deluty, Jennifer

AU - Zimmerman, Molly E.

AU - Crandall, Jill P.

AU - Barzilai, Nir

AU - Melamed, Michal L.

AU - Atzmon, Gil

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N2 - Objectives To define vitamin D levels and their association with cognition in subjects with exceptional longevity. Design Cross-sectional. Setting Community and long-term care facilities. Participants Ashkenazi Jewish subjects (n = 253) with exceptional longevity, with comparison made to the Third National Health and Nutrition Examination Survey (NHANES III) participants aged 70 and older. Measurements Serum 25-hydroxyvitamin D levels were measured using liquid chromatography/tandem mass spectrometry analysis. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and clock drawing test (CDT: command and copy). Results The median age of the Ashkenazi subjects was 97 (interquartile range (IQR) 95-104). Age-associated rise in the prevalence of vitamin D insufficiency, defined as a serum vitamin D level of less than 30 ng/mL, was noted in NHANES III (P =.001). In the Ashkenazi group with longevity, the rate of vitamin D insufficiency was comparable with that of the NHANES III participants, who were up to 25 years younger. In the cohort with exceptional longevity, 49% demonstrated cognitive impairment as assessed according to MMSE score (impaired cognition, median 9.5 IQR 0-24); normal cognition, median 29 (IQR 18-30) P <.001). Vitamin D insufficiency was more prevalent in those with impaired cognition, defined according to the MMSE (71.8% vs 57.7%, P =.02) and the CDT copy (84.6% vs. 50.6%, P =.02), than in those with normal cognition. This association remained significant after multivariable adjustment in logistic regression models for cognitive assessments made using the MMSE (odds ratio (OR) = 3.2, 95% confidence interval (CI) = 1.1-9.29, P =.03) and the CDT copy (OR = 8.96, 95% CI = 1.08-74.69, P =.04). Conclusion Higher vitamin D levels may be a marker of delayed aging, because they are associated with better cognitive function in people achieving exceptional longevity.

AB - Objectives To define vitamin D levels and their association with cognition in subjects with exceptional longevity. Design Cross-sectional. Setting Community and long-term care facilities. Participants Ashkenazi Jewish subjects (n = 253) with exceptional longevity, with comparison made to the Third National Health and Nutrition Examination Survey (NHANES III) participants aged 70 and older. Measurements Serum 25-hydroxyvitamin D levels were measured using liquid chromatography/tandem mass spectrometry analysis. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and clock drawing test (CDT: command and copy). Results The median age of the Ashkenazi subjects was 97 (interquartile range (IQR) 95-104). Age-associated rise in the prevalence of vitamin D insufficiency, defined as a serum vitamin D level of less than 30 ng/mL, was noted in NHANES III (P =.001). In the Ashkenazi group with longevity, the rate of vitamin D insufficiency was comparable with that of the NHANES III participants, who were up to 25 years younger. In the cohort with exceptional longevity, 49% demonstrated cognitive impairment as assessed according to MMSE score (impaired cognition, median 9.5 IQR 0-24); normal cognition, median 29 (IQR 18-30) P <.001). Vitamin D insufficiency was more prevalent in those with impaired cognition, defined according to the MMSE (71.8% vs 57.7%, P =.02) and the CDT copy (84.6% vs. 50.6%, P =.02), than in those with normal cognition. This association remained significant after multivariable adjustment in logistic regression models for cognitive assessments made using the MMSE (odds ratio (OR) = 3.2, 95% confidence interval (CI) = 1.1-9.29, P =.03) and the CDT copy (OR = 8.96, 95% CI = 1.08-74.69, P =.04). Conclusion Higher vitamin D levels may be a marker of delayed aging, because they are associated with better cognitive function in people achieving exceptional longevity.

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