Abstract
In addition to its widespread clinical use, the intracranial electroencephalogram (iEEG) is increasingly being employed as a tool to map the neural correlates of normal cognitive function as well as for developing neuroprosthetics. Despite recent advances, and unlike other established brain-mapping modalities (e.g. functional MRI, magneto- and electroencephalography), registering the iEEG with respect to neuroanatomy in individuals-and coregistering functional results across subjects-remains a significant challenge. Here we describe a method which coregisters high-resolution preoperative MRI with postoperative computerized tomography (CT) for the purpose of individualized functional mapping of both normal and pathological (e.g., interictal discharges and seizures) brain activity. Our method accurately (within 3. mm, on average) localizes electrodes with respect to an individual's neuroanatomy. Furthermore, we outline a principled procedure for either volumetric or surface-based group analyses. We demonstrate our method in five patients with medically-intractable epilepsy undergoing invasive monitoring of the seizure focus prior to its surgical removal. The straight-forward application of this procedure to all types of intracranial electrodes, robustness to deformations in both skull and brain, and the ability to compare electrode locations across groups of patients makes this procedure an important tool for basic scientists as well as clinicians.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3563-3570 |
| Number of pages | 8 |
| Journal | NeuroImage |
| Volume | 59 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 15 2012 |
| Externally published | Yes |
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Keywords
- CT
- Electrocorticography
- Epilepsy
- Image registration
- MRI
ASJC Scopus subject areas
- Cognitive Neuroscience
- Neurology
Cite this
Individualized localization and cortical surface-based registration of intracranial electrodes. / Dykstra, Andrew R.; Chan, Alexander M.; Quinn, Brian T.; Zepeda, Rodrigo; Keller, Corey J.; Cormier, Justine; Madsen, Joseph R.; Eskandar, Emad N.; Cash, Sydney S.
In: NeuroImage, Vol. 59, No. 4, 15.02.2012, p. 3563-3570.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Individualized localization and cortical surface-based registration of intracranial electrodes
AU - Dykstra, Andrew R.
AU - Chan, Alexander M.
AU - Quinn, Brian T.
AU - Zepeda, Rodrigo
AU - Keller, Corey J.
AU - Cormier, Justine
AU - Madsen, Joseph R.
AU - Eskandar, Emad N.
AU - Cash, Sydney S.
PY - 2012/2/15
Y1 - 2012/2/15
N2 - In addition to its widespread clinical use, the intracranial electroencephalogram (iEEG) is increasingly being employed as a tool to map the neural correlates of normal cognitive function as well as for developing neuroprosthetics. Despite recent advances, and unlike other established brain-mapping modalities (e.g. functional MRI, magneto- and electroencephalography), registering the iEEG with respect to neuroanatomy in individuals-and coregistering functional results across subjects-remains a significant challenge. Here we describe a method which coregisters high-resolution preoperative MRI with postoperative computerized tomography (CT) for the purpose of individualized functional mapping of both normal and pathological (e.g., interictal discharges and seizures) brain activity. Our method accurately (within 3. mm, on average) localizes electrodes with respect to an individual's neuroanatomy. Furthermore, we outline a principled procedure for either volumetric or surface-based group analyses. We demonstrate our method in five patients with medically-intractable epilepsy undergoing invasive monitoring of the seizure focus prior to its surgical removal. The straight-forward application of this procedure to all types of intracranial electrodes, robustness to deformations in both skull and brain, and the ability to compare electrode locations across groups of patients makes this procedure an important tool for basic scientists as well as clinicians.
AB - In addition to its widespread clinical use, the intracranial electroencephalogram (iEEG) is increasingly being employed as a tool to map the neural correlates of normal cognitive function as well as for developing neuroprosthetics. Despite recent advances, and unlike other established brain-mapping modalities (e.g. functional MRI, magneto- and electroencephalography), registering the iEEG with respect to neuroanatomy in individuals-and coregistering functional results across subjects-remains a significant challenge. Here we describe a method which coregisters high-resolution preoperative MRI with postoperative computerized tomography (CT) for the purpose of individualized functional mapping of both normal and pathological (e.g., interictal discharges and seizures) brain activity. Our method accurately (within 3. mm, on average) localizes electrodes with respect to an individual's neuroanatomy. Furthermore, we outline a principled procedure for either volumetric or surface-based group analyses. We demonstrate our method in five patients with medically-intractable epilepsy undergoing invasive monitoring of the seizure focus prior to its surgical removal. The straight-forward application of this procedure to all types of intracranial electrodes, robustness to deformations in both skull and brain, and the ability to compare electrode locations across groups of patients makes this procedure an important tool for basic scientists as well as clinicians.
KW - CT
KW - Electrocorticography
KW - Epilepsy
KW - Image registration
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=84855161921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855161921&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2011.11.046
DO - 10.1016/j.neuroimage.2011.11.046
M3 - Article
C2 - 22155045
AN - SCOPUS:84855161921
VL - 59
SP - 3563
EP - 3570
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 4
ER -