Indirect prediction of fetal lung maturity: Value of ultrasonographic colonic and placental grading

J. Ricardo Loret De Mola, Nancy Judge, Carmela Entsminger, Marina DeViney, Kevin L. Muise, Method A. Duchon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVE: To correlate fetal morphometrics with studies of fetal lung maturity. STUDY DESIGN: One hundred six patients undergoing amniocentesis for fetal lung maturity studies were examined prospectively. Eighty-four patients were normal (79%), and 22 were diabetic (21%). Fetal morphometrics were obtained prior to amniocentesis. The fetal colon and placenta were graded. Discriminant analysis was used to identify variables that were predictive of a mature lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol (PG). All patients delivered within 48 hours of amniocentesis. RESULTS: In the normal group, 28 (33%) fetuses had a grade 3 colon, which was 68% sensitive and 98% specific for a mature amniocentesis. A grade 3 colon was the single best predictor of a mature amniocentesis (P < .001). Twenty-five (29%) fetuses had a grade 3 placenta, which was 64% sensitive and 96% specific for a mature amniocentesis (P < .005). Diabetes did not influence colonic grading since a grade 3 colon was present in seven (32%) patients (47% sensitivity and 100% specificity/or PG) (P < .02). Interexaminer and intraexaminer variability/or the study was excellent, κ=1.0 (P < .001). CONCLUSION: Colonic and placental stage 3 grading are reliable and reproducible ultrasonographic scales that can help predict the findings of fetal lung maturity studies.

Original languageEnglish (US)
Pages (from-to)898-902
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number10
StatePublished - Oct 1 1998
Externally publishedYes


  • Fetal organ maturity
  • Gestational diabetes
  • Prenatal diagnosis
  • Prenatal diagnosis, ultrasonic

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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