Indirect prediction of fetal lung maturity: Value of ultrasonographic colonic and placental grading

J. Ricardo Loret De Mola, Nancy E. Judge, Carmela Entsminger, Marina DeViney, Kevin L. Muise, Method A. Duchon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: To correlate fetal morphometrics with studies of fetal lung maturity. STUDY DESIGN: One hundred six patients undergoing amniocentesis for fetal lung maturity studies were examined prospectively. Eighty-four patients were normal (79%), and 22 were diabetic (21%). Fetal morphometrics were obtained prior to amniocentesis. The fetal colon and placenta were graded. Discriminant analysis was used to identify variables that were predictive of a mature lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol (PG). All patients delivered within 48 hours of amniocentesis. RESULTS: In the normal group, 28 (33%) fetuses had a grade 3 colon, which was 68% sensitive and 98% specific for a mature amniocentesis. A grade 3 colon was the single best predictor of a mature amniocentesis (P < .001). Twenty-five (29%) fetuses had a grade 3 placenta, which was 64% sensitive and 96% specific for a mature amniocentesis (P < .005). Diabetes did not influence colonic grading since a grade 3 colon was present in seven (32%) patients (47% sensitivity and 100% specificity/or PG) (P < .02). Interexaminer and intraexaminer variability/or the study was excellent, κ=1.0 (P < .001). CONCLUSION: Colonic and placental stage 3 grading are reliable and reproducible ultrasonographic scales that can help predict the findings of fetal lung maturity studies.

Original languageEnglish (US)
Pages (from-to)898-902
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume43
Issue number10
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Amniocentesis
Lung
Colon
Phosphatidylglycerols
Placenta
Fetus
Sphingomyelins
Lecithins
Discriminant Analysis
Sensitivity and Specificity

Keywords

  • Fetal organ maturity
  • Gestational diabetes
  • Prenatal diagnosis
  • Prenatal diagnosis, ultrasonic

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Indirect prediction of fetal lung maturity : Value of ultrasonographic colonic and placental grading. / De Mola, J. Ricardo Loret; Judge, Nancy E.; Entsminger, Carmela; DeViney, Marina; Muise, Kevin L.; Duchon, Method A.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 43, No. 10, 10.1998, p. 898-902.

Research output: Contribution to journalArticle

De Mola, J. Ricardo Loret ; Judge, Nancy E. ; Entsminger, Carmela ; DeViney, Marina ; Muise, Kevin L. ; Duchon, Method A. / Indirect prediction of fetal lung maturity : Value of ultrasonographic colonic and placental grading. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1998 ; Vol. 43, No. 10. pp. 898-902.
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abstract = "OBJECTIVE: To correlate fetal morphometrics with studies of fetal lung maturity. STUDY DESIGN: One hundred six patients undergoing amniocentesis for fetal lung maturity studies were examined prospectively. Eighty-four patients were normal (79{\%}), and 22 were diabetic (21{\%}). Fetal morphometrics were obtained prior to amniocentesis. The fetal colon and placenta were graded. Discriminant analysis was used to identify variables that were predictive of a mature lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol (PG). All patients delivered within 48 hours of amniocentesis. RESULTS: In the normal group, 28 (33{\%}) fetuses had a grade 3 colon, which was 68{\%} sensitive and 98{\%} specific for a mature amniocentesis. A grade 3 colon was the single best predictor of a mature amniocentesis (P < .001). Twenty-five (29{\%}) fetuses had a grade 3 placenta, which was 64{\%} sensitive and 96{\%} specific for a mature amniocentesis (P < .005). Diabetes did not influence colonic grading since a grade 3 colon was present in seven (32{\%}) patients (47{\%} sensitivity and 100{\%} specificity/or PG) (P < .02). Interexaminer and intraexaminer variability/or the study was excellent, κ=1.0 (P < .001). CONCLUSION: Colonic and placental stage 3 grading are reliable and reproducible ultrasonographic scales that can help predict the findings of fetal lung maturity studies.",
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AU - Muise, Kevin L.

AU - Duchon, Method A.

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