Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms

Shitij Arora; Anurag Mehrotra; Subhash C. Gulati

doi:10.1016/j.canlet.2012.04.002

Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms

Shitij Arora, Anurag Mehrotra, Subhash C. Gulati

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of intense investigation. Several trials are underway assessing the effect of adding metformin to the existing chemotherapy regimen in the treatment of cancers. This review has a focus on other commonly used drugs classified into two broad groups, incretins and thiazolidinediones. The aim of this review is to discuss the common genetic polymorphisms implicated in the pathogenesis of type 2 diabetes mellitus (type 2 DM) and how they are linked to molecular pathways involved in carcinogenesis.

Original language	English (US)
Pages (from-to)	128-134
Number of pages	7
Journal	Cancer Letters
Volume	323
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.04.002
State	Published - Oct 28 2012
Externally published	Yes

Keywords

Oncogenesis
PPARγ
Thiazolidinediones
Transcription factor 7 like 2

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.04.002

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title = "Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms",

abstract = "With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of intense investigation. Several trials are underway assessing the effect of adding metformin to the existing chemotherapy regimen in the treatment of cancers. This review has a focus on other commonly used drugs classified into two broad groups, incretins and thiazolidinediones. The aim of this review is to discuss the common genetic polymorphisms implicated in the pathogenesis of type 2 diabetes mellitus (type 2 DM) and how they are linked to molecular pathways involved in carcinogenesis.",

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doi = "10.1016/j.canlet.2012.04.002",

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T1 - Incretins and thiazolidinediones in glucose homeostasis and cancer

T2 - Role of common polymorphisms

AU - Arora, Shitij

AU - Mehrotra, Anurag

AU - Gulati, Subhash C.

PY - 2012/10/28

Y1 - 2012/10/28

N2 - With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of intense investigation. Several trials are underway assessing the effect of adding metformin to the existing chemotherapy regimen in the treatment of cancers. This review has a focus on other commonly used drugs classified into two broad groups, incretins and thiazolidinediones. The aim of this review is to discuss the common genetic polymorphisms implicated in the pathogenesis of type 2 diabetes mellitus (type 2 DM) and how they are linked to molecular pathways involved in carcinogenesis.

AB - With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of intense investigation. Several trials are underway assessing the effect of adding metformin to the existing chemotherapy regimen in the treatment of cancers. This review has a focus on other commonly used drugs classified into two broad groups, incretins and thiazolidinediones. The aim of this review is to discuss the common genetic polymorphisms implicated in the pathogenesis of type 2 diabetes mellitus (type 2 DM) and how they are linked to molecular pathways involved in carcinogenesis.

KW - Oncogenesis

KW - PPARγ

KW - Thiazolidinediones

KW - Transcription factor 7 like 2

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DO - 10.1016/j.canlet.2012.04.002

M3 - Review article

C2 - 22521548

AN - SCOPUS:84863091302

SN - 0304-3835

VL - 323

SP - 128

EP - 134

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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