Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms

Shitij Arora, Anurag Mehrotra, Subhash C. Gulati

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of intense investigation. Several trials are underway assessing the effect of adding metformin to the existing chemotherapy regimen in the treatment of cancers. This review has a focus on other commonly used drugs classified into two broad groups, incretins and thiazolidinediones. The aim of this review is to discuss the common genetic polymorphisms implicated in the pathogenesis of type 2 diabetes mellitus (type 2 DM) and how they are linked to molecular pathways involved in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalCancer Letters
Volume323
Issue number2
DOIs
Publication statusPublished - Oct 28 2012
Externally publishedYes

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Keywords

  • Oncogenesis
  • PPARγ
  • Thiazolidinediones
  • Transcription factor 7 like 2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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