Increases in Neuroticism May Be an Early Indicator of Dementia: A Coordinated Analysis

Tomiko Yoneda, Jonathan Rush, Eileen K. Graham, Anne Ingeborg Berg, Hannie Comijs, Mindy Katz, Richard B. Lipton, Boo Johansson, Daniel K. Mroczek, Andrea M. Piccinin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objectives: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. Methods: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). Results: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. Discussion: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.

Original languageEnglish (US)
Pages (from-to)251-262
Number of pages12
JournalJournals of Gerontology - Series B Psychological Sciences and Social Sciences
Issue number2
StatePublished - Jan 14 2020


  • Longitudinal change
  • Mild cognitive impairment
  • Multi-study conceptual replication
  • Personality

ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Life-span and Life-course Studies


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