Increases in Neuroticism May Be an Early Indicator of Dementia: A Coordinated Analysis

Tomiko Yoneda, Jonathan Rush, Eileen K. Graham, Anne Ingeborg Berg, Hannie Comijs, Mindy Katz, Richard B. Lipton, Boo Johansson, Daniel K. Mroczek, Andrea M. Piccinin

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. METHODS: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). RESULTS: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. DISCUSSION: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.

Original languageEnglish (US)
Pages (from-to)251-262
Number of pages12
JournalThe journals of gerontology. Series B, Psychological sciences and social sciences
Volume75
Issue number2
DOIs
StatePublished - Jan 14 2020

Fingerprint

neuroticism
dementia
Dementia
Personality
personality traits
personality change
Longitudinal Studies
indication
incident
overtime
gerontology
Sex Education
Social Sciences
Growth
Neuroticism
Geriatrics
longitudinal study
education
social science
Prospective Studies

Keywords

  • Longitudinal change
  • Mild cognitive impairment
  • Multi-study conceptual replication
  • Personality

ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Life-span and Life-course Studies

Cite this

Increases in Neuroticism May Be an Early Indicator of Dementia : A Coordinated Analysis. / Yoneda, Tomiko; Rush, Jonathan; Graham, Eileen K.; Berg, Anne Ingeborg; Comijs, Hannie; Katz, Mindy; Lipton, Richard B.; Johansson, Boo; Mroczek, Daniel K.; Piccinin, Andrea M.

In: The journals of gerontology. Series B, Psychological sciences and social sciences, Vol. 75, No. 2, 14.01.2020, p. 251-262.

Research output: Contribution to journalArticle

Yoneda, Tomiko ; Rush, Jonathan ; Graham, Eileen K. ; Berg, Anne Ingeborg ; Comijs, Hannie ; Katz, Mindy ; Lipton, Richard B. ; Johansson, Boo ; Mroczek, Daniel K. ; Piccinin, Andrea M. / Increases in Neuroticism May Be an Early Indicator of Dementia : A Coordinated Analysis. In: The journals of gerontology. Series B, Psychological sciences and social sciences. 2020 ; Vol. 75, No. 2. pp. 251-262.
@article{b7a0dbbd8f7544389ea198f905869e05,
title = "Increases in Neuroticism May Be an Early Indicator of Dementia: A Coordinated Analysis",
abstract = "OBJECTIVES: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. METHODS: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). RESULTS: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. DISCUSSION: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.",
keywords = "Longitudinal change, Mild cognitive impairment, Multi-study conceptual replication, Personality",
author = "Tomiko Yoneda and Jonathan Rush and Graham, {Eileen K.} and Berg, {Anne Ingeborg} and Hannie Comijs and Mindy Katz and Lipton, {Richard B.} and Boo Johansson and Mroczek, {Daniel K.} and Piccinin, {Andrea M.}",
year = "2020",
month = "1",
day = "14",
doi = "10.1093/geronb/gby034",
language = "English (US)",
volume = "75",
pages = "251--262",
journal = "Journals of Gerontology - Series B Psychological Sciences and Social Sciences",
issn = "1079-5014",
publisher = "Gerontological Society of America",
number = "2",

}

TY - JOUR

T1 - Increases in Neuroticism May Be an Early Indicator of Dementia

T2 - A Coordinated Analysis

AU - Yoneda, Tomiko

AU - Rush, Jonathan

AU - Graham, Eileen K.

AU - Berg, Anne Ingeborg

AU - Comijs, Hannie

AU - Katz, Mindy

AU - Lipton, Richard B.

AU - Johansson, Boo

AU - Mroczek, Daniel K.

AU - Piccinin, Andrea M.

PY - 2020/1/14

Y1 - 2020/1/14

N2 - OBJECTIVES: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. METHODS: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). RESULTS: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. DISCUSSION: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.

AB - OBJECTIVES: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. METHODS: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). RESULTS: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. DISCUSSION: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.

KW - Longitudinal change

KW - Mild cognitive impairment

KW - Multi-study conceptual replication

KW - Personality

UR - http://www.scopus.com/inward/record.url?scp=85077940759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077940759&partnerID=8YFLogxK

U2 - 10.1093/geronb/gby034

DO - 10.1093/geronb/gby034

M3 - Article

C2 - 29608748

AN - SCOPUS:85077940759

VL - 75

SP - 251

EP - 262

JO - Journals of Gerontology - Series B Psychological Sciences and Social Sciences

JF - Journals of Gerontology - Series B Psychological Sciences and Social Sciences

SN - 1079-5014

IS - 2

ER -