Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor

B. A. Rocha, K. Scearce-Levie, J. J. Lucas, Noboru Hiroi, N. Castanon, J. C. Crabbe, E. J. Nestler, R. Hen

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

There is increasing evidence that genetic factors can influence individual differences in vulnerability to drugs of abuse. Serotonin (5- hydroxytryptamine, 5-HT), acting through many receptors can modulate the activity of neural reward pathways and thus the effects of various drugs of abuse. Here we examine the effects of cocaine in mice lacking one of the serotonin-receptor subtypes, the 5-HT(1B) receptor. We show that mice lacking 5-HT(1B) display increased locomotor responses to cocaine and that they are more motivated to self-administer cocaine. We propose that even drug-naive 5- HT(1B)-knockout mice are in a behavioural and biochemical state that resembles that of wild-type mice sensitized to cocaine by repeated exposure to the drug. This altered state might be responsible for their increased vulnerability to cocaine.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalNature
Volume393
Issue number6681
DOIs
StatePublished - May 14 1998
Externally publishedYes

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Cocaine
Serotonin
Street Drugs
Receptor, Serotonin, 5-HT1B
Neural Pathways
Serotonin Receptors
Reward
Knockout Mice
Individuality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Rocha, B. A., Scearce-Levie, K., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., ... Hen, R. (1998). Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor. Nature, 393(6681), 175-178. https://doi.org/10.1038/30259

Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor. / Rocha, B. A.; Scearce-Levie, K.; Lucas, J. J.; Hiroi, Noboru; Castanon, N.; Crabbe, J. C.; Nestler, E. J.; Hen, R.

In: Nature, Vol. 393, No. 6681, 14.05.1998, p. 175-178.

Research output: Contribution to journalArticle

Rocha, BA, Scearce-Levie, K, Lucas, JJ, Hiroi, N, Castanon, N, Crabbe, JC, Nestler, EJ & Hen, R 1998, 'Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor', Nature, vol. 393, no. 6681, pp. 175-178. https://doi.org/10.1038/30259
Rocha BA, Scearce-Levie K, Lucas JJ, Hiroi N, Castanon N, Crabbe JC et al. Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor. Nature. 1998 May 14;393(6681):175-178. https://doi.org/10.1038/30259
Rocha, B. A. ; Scearce-Levie, K. ; Lucas, J. J. ; Hiroi, Noboru ; Castanon, N. ; Crabbe, J. C. ; Nestler, E. J. ; Hen, R. / Increased vulnerability to cocaine in mice lacking the serotonin-1 B receptor. In: Nature. 1998 ; Vol. 393, No. 6681. pp. 175-178.
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