Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors

Paul J. Gaglio, Srikar Malireddy, Brian S. Levitt, Dianne Lapointe-Rudow, Jay Lefkowitch, Milan Kinkhabwala, Mark W. Russo, Jean C. Emond, Robert S. Brown

Research output: Contribution to journalArticle

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Abstract

Histologic injury cause by recurrent hepatitis C virus (HCV) has been reported in up to 90% of HCV-infected patients who undergo liver transplantation with a cadaveric graft. However, the natural history of HCV after living donor liver transplantation (LDLT) is not well described. We performed a retrospective analysis of 68 consecutive HCV-infected adult patients: 45 recipients of cadaveric grafts (CAD) were compared with 23 LDLT patients. Elevated serum transaminases, positive HCV RNA, and liver biopsy consistent with histologic evidence of HCV defined recurrence. When comparing CAD with LDLT, both the incidence of HCV recurrence and time to recurrence were not different. The overall incidence of severe sequelae of HCV recurrence, either cholestatic hepatitis, grade III-IV inflammation, and/or HCV-induced graft failure requiring retransplantation, was also not different when comparing CAD with LDLT. However, when comparing CAD versus LDLT, no CAD patient developed cholestatic hepatitis C, compared with 17% of LDLT who developed this complication (P = .001). Thus, in this patient population, the timing and incidence of HCV recurrence were not different when comparing CAD versus LDLT, but the incidence of cholestatic hepatitis was significantly greater in patients with HCV who underwent LDLT.

Original languageEnglish (US)
Pages (from-to)1028-1035
Number of pages8
JournalLiver Transplantation
Volume9
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Hepatitis C
Hepacivirus
Living Donors
Liver Transplantation
Tissue Donors
Transplants
Liver
Recurrence
Incidence
Hepatitis
Transaminases
Natural History
RNA
Inflammation
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Gaglio, P. J., Malireddy, S., Levitt, B. S., Lapointe-Rudow, D., Lefkowitch, J., Kinkhabwala, M., ... Brown, R. S. (2003). Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors. Liver Transplantation, 9(10), 1028-1035. https://doi.org/10.1053/jlts.2003.50211

Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors. / Gaglio, Paul J.; Malireddy, Srikar; Levitt, Brian S.; Lapointe-Rudow, Dianne; Lefkowitch, Jay; Kinkhabwala, Milan; Russo, Mark W.; Emond, Jean C.; Brown, Robert S.

In: Liver Transplantation, Vol. 9, No. 10, 10.2003, p. 1028-1035.

Research output: Contribution to journalArticle

Gaglio, PJ, Malireddy, S, Levitt, BS, Lapointe-Rudow, D, Lefkowitch, J, Kinkhabwala, M, Russo, MW, Emond, JC & Brown, RS 2003, 'Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors', Liver Transplantation, vol. 9, no. 10, pp. 1028-1035. https://doi.org/10.1053/jlts.2003.50211
Gaglio, Paul J. ; Malireddy, Srikar ; Levitt, Brian S. ; Lapointe-Rudow, Dianne ; Lefkowitch, Jay ; Kinkhabwala, Milan ; Russo, Mark W. ; Emond, Jean C. ; Brown, Robert S. / Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors. In: Liver Transplantation. 2003 ; Vol. 9, No. 10. pp. 1028-1035.
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