Increased phase synchronization between intracranial pressure and arterial blood pressure during elevated intracranial pressure in dogs

R. Zou, E. McCormack, M. Egnor, D. Kim, M. Wagshul, B. MacDonald, J. R. Madsen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We applied the concept of "phase synchronization" from nonlinear dynamics to the complex relationship between intracranial pressure (ICP) and arterial blood pressure (ABP) signals. This method is based on multiresolution wavelet transform (MRWT) in which the signals are divided into different frequency bands. We examined ICP and ABP signals from anaesthetized dogs, exploring normal ICP and elevated ICP by 1∼3 ml injection of saline into the cerebral ventricles. Phase synchronization analyses show an interesting phenomenon of phase reset from relatively uniform phase distribution to phase clustering around 0° after injection. To further quantitatively measure phase synchronization, phase coherence is used to distinguish the dynamics of normal ICP and elevated ICP by saline injection. Elevated ICP exhibits higher phase coherence than that of normal ICP, The results suggest that the association between ICP and ABP may involve nonlinear mechanisms of regulation. The clinical application of this method is in investigation.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages315-318
Number of pages4
ISBN (Print)0780387406, 9780780387409
DOIs
StatePublished - 2005
Externally publishedYes
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Zou, R., McCormack, E., Egnor, M., Kim, D., Wagshul, M., MacDonald, B., & Madsen, J. R. (2005). Increased phase synchronization between intracranial pressure and arterial blood pressure during elevated intracranial pressure in dogs. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 315-318). [1616408] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/iembs.2005.1616408