Increased norepinephrine variability in patients with sleep apnea syndrome

Peter Baylor, Andrew Mouton, Harry Shamoon, Paul Goebel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: To assess the plasma arterial catecholamine response to nocturnal desaturation in a group of patients with a history suggestive of sleep apnea. PARENTS AND METHODS: At a Veterans Affairs hospital, 10 patients who had a history consistent with sleep apnea syndrome were involved in the study. Arterial plasma catecholamines were measured at varying intervals during a 5 1/2 -hour sleep study. Eighteen samples per patient were analyzed. RESULTS: As the hemoglobin saturation decreased, the variability in plasma norepinephrine increased significantly (r = -.78, P = 0.004). As the hemoglobin saturation fell, there was a trend towards higher concentrations of plasma norepinephrine (r = -.53, P = 0.06). As the hemoglobin saturation decreased, the variability in plasma epinephrine concentration was net significant (r = .42). CONCLUSION: The association between the degree of desaturation and the variability in norepinephrine suggests that norepinephrine is released in response to nocturnal desaturation.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalAmerican Journal of Medicine
Volume99
Issue number6
DOIs
StatePublished - 1995

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Sleep Apnea Syndromes
Norepinephrine
Hemoglobins
Catecholamines
History
Veterans Hospitals
Epinephrine
Sleep

ASJC Scopus subject areas

  • Nursing(all)

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Increased norepinephrine variability in patients with sleep apnea syndrome. / Baylor, Peter; Mouton, Andrew; Shamoon, Harry; Goebel, Paul.

In: American Journal of Medicine, Vol. 99, No. 6, 1995, p. 611-615.

Research output: Contribution to journalArticle

Baylor, Peter ; Mouton, Andrew ; Shamoon, Harry ; Goebel, Paul. / Increased norepinephrine variability in patients with sleep apnea syndrome. In: American Journal of Medicine. 1995 ; Vol. 99, No. 6. pp. 611-615.
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