Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Erik Mullaart; Michael E.T.I. Boerrigter; Rivka Ravid; Dick F. Swaab; Jan Vijg

doi:10.1016/0197-4580(90)90542-8

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Erik Mullaart, Michael E.T.I. Boerrigter, Rivka Ravid, Dick F. Swaab, Jan Vijg

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Neurobiology of Aging
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0197-4580(90)90542-8
State	Published - 1990
Externally published	Yes

Keywords

Alkaline elution
Alzheimer's disease
Cerebral cortex
DNA breaks

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Access to Document

10.1016/0197-4580(90)90542-8

Cite this

@article{23114739bb1944fabaff75daa6f426b4,

title = "Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients",

abstract = "It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.",

keywords = "Alkaline elution, Alzheimer's disease, Cerebral cortex, DNA breaks",

author = "Erik Mullaart and Boerrigter, {Michael E.T.I.} and Rivka Ravid and Swaab, {Dick F.} and Jan Vijg",

year = "1990",

doi = "10.1016/0197-4580(90)90542-8",

language = "English (US)",

volume = "11",

pages = "169--173",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

AU - Mullaart, Erik

AU - Boerrigter, Michael E.T.I.

AU - Ravid, Rivka

AU - Swaab, Dick F.

AU - Vijg, Jan

PY - 1990

Y1 - 1990

N2 - It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

AB - It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

KW - Alkaline elution

KW - Alzheimer's disease

KW - Cerebral cortex

KW - DNA breaks

UR - http://www.scopus.com/inward/record.url?scp=0025297786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025297786&partnerID=8YFLogxK

U2 - 10.1016/0197-4580(90)90542-8

DO - 10.1016/0197-4580(90)90542-8

M3 - Article

C2 - 2362649

AN - SCOPUS:0025297786

SN - 0197-4580

VL - 11

SP - 169

EP - 173

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 3

ER -

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this