Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Erik Mullaart, Michael E T I Boerrigter, Rivka Ravid, Dick F. Swaab, Jan Vijg

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalNeurobiology of Aging
Volume11
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

DNA Breaks
Cerebral Cortex
Alzheimer Disease
DNA Damage
DNA Repair
Alkalies
Autopsy

Keywords

  • Alkaline elution
  • Alzheimer's disease
  • Cerebral cortex
  • DNA breaks

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. / Mullaart, Erik; Boerrigter, Michael E T I; Ravid, Rivka; Swaab, Dick F.; Vijg, Jan.

In: Neurobiology of Aging, Vol. 11, No. 3, 1990, p. 169-173.

Research output: Contribution to journalArticle

Mullaart, Erik ; Boerrigter, Michael E T I ; Ravid, Rivka ; Swaab, Dick F. ; Vijg, Jan. / Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. In: Neurobiology of Aging. 1990 ; Vol. 11, No. 3. pp. 169-173.
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