Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members

Melissa A. Brotman; Melissa H. Rooney; Martha Skup; Daniel S. Pine; Ellen Leibenluft

doi:10.1097/CHI.0b013e3181a27527

Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members

Melissa A. Brotman, Melissa H. Rooney, Martha Skup, Daniel S. Pine, Ellen Leibenluft

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT. Method: Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years. Subjects completed the Flanker Continuous Performance Test. Results: Bipolar disorder and at-risk youths had increased lSV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths. Conclusions: Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc.

Original language	English (US)
Pages (from-to)	628-635
Number of pages	8
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	48
Issue number	6
DOIs	https://doi.org/10.1097/CHI.0b013e3181a27527
State	Published - Jun 2009
Externally published	Yes

Keywords

Bipolar disorder
Endophenotype
Sustained attention

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/CHI.0b013e3181a27527

Cite this

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title = "Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members",

abstract = "Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT. Method: Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years. Subjects completed the Flanker Continuous Performance Test. Results: Bipolar disorder and at-risk youths had increased lSV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths. Conclusions: Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc.",

keywords = "Bipolar disorder, Endophenotype, Sustained attention",

author = "Brotman, {Melissa A.} and Rooney, {Melissa H.} and Martha Skup and Pine, {Daniel S.} and Ellen Leibenluft",

note = "Funding Information: Funding support for this work was provided by the Intramural Research Program of the National Institute of Mental Health. Funding support for Melissa H. Rooney was provided through the Clinical Research Training Program, a public-private partnership supported jointly by the National Institutes of Health (NIH) and Pfizer (via a grant to the Foundation for NIH from Pfizer). ",

year = "2009",

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doi = "10.1097/CHI.0b013e3181a27527",

language = "English (US)",

volume = "48",

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T1 - Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members

AU - Brotman, Melissa A.

AU - Rooney, Melissa H.

AU - Skup, Martha

AU - Pine, Daniel S.

AU - Leibenluft, Ellen

N1 - Funding Information: Funding support for this work was provided by the Intramural Research Program of the National Institute of Mental Health. Funding support for Melissa H. Rooney was provided through the Clinical Research Training Program, a public-private partnership supported jointly by the National Institutes of Health (NIH) and Pfizer (via a grant to the Foundation for NIH from Pfizer).

PY - 2009/6

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N2 - Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT. Method: Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years. Subjects completed the Flanker Continuous Performance Test. Results: Bipolar disorder and at-risk youths had increased lSV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths. Conclusions: Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc.

AB - Objective: Deficits in sustained attention may represent an endophenotype for bipolar disorder (BD). One heritable measure of sustained attention is intrasubject variability in response time (ISV-RT). We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT. Method: Subjects were 28 patients with BD, 26 unaffected youths with a first-degree relative with BD, and 24 control youths without an affected relative, all aged 7 to 17 years. Subjects completed the Flanker Continuous Performance Test. Results: Bipolar disorder and at-risk youths had increased lSV-RT, compared with the controls. Differences were independent of comorbid psychopathology in youths with BD and present in psychiatrically healthy at-risk youths. Conclusions: Increased ISV-RT may be a risk marker for BD. Further research is needed to investigate the neural and genetic underpinnings of this deficit, as well as the specificity of the finding to BD. J. Am. Acad. Child Adolesc.

KW - Bipolar disorder

KW - Endophenotype

KW - Sustained attention

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Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members

Abstract

Keywords

ASJC Scopus subject areas

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