Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies

Jong Hee Hwang, Daniel T. Stein, Nir Barzilai, Min-Hui Cui, Julia Tonelli, Preeti Kishore, Meredith A. Hawkins

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF), and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were 1) to simultaneously measure IMCL, IHTG, VF, and abdominal SF in the same nondiabetic individuals using noninvasive 1H-magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (R d) during euglycemic-hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG, and VF. There were significant inverse correlations between whole body Rd and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body Rd (r = -0.86, P < 0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume293
Issue number6
DOIs
StatePublished - Dec 2007

Fingerprint

Vascular Resistance
Intra-Abdominal Fat
Insulin Resistance
Triglycerides
Magnetic Resonance Spectroscopy
Fats
Spectroscopy
Insulin
Imaging techniques
Abdominal Subcutaneous Fat
Lipids
Glucose Clamp Technique
Liver
Magnetic resonance spectroscopy
Magnetic Resonance Imaging
Clamping devices
Magnetic resonance
Glucose
Tissue

Keywords

  • Adipokines
  • In vivo magnetic resonance imaging and spectroscopy
  • Leptin
  • Muscle and visceral fat

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

@article{8d160abe173f469facaf4559e63cb5aa,
title = "Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies",
abstract = "Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF), and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were 1) to simultaneously measure IMCL, IHTG, VF, and abdominal SF in the same nondiabetic individuals using noninvasive 1H-magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (R d) during euglycemic-hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG, and VF. There were significant inverse correlations between whole body Rd and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body Rd (r = -0.86, P < 0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.",
keywords = "Adipokines, In vivo magnetic resonance imaging and spectroscopy, Leptin, Muscle and visceral fat",
author = "Hwang, {Jong Hee} and Stein, {Daniel T.} and Nir Barzilai and Min-Hui Cui and Julia Tonelli and Preeti Kishore and Hawkins, {Meredith A.}",
year = "2007",
month = "12",
doi = "10.1152/ajpendo.00590.2006",
language = "English (US)",
volume = "293",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Increased intrahepatic triglyceride is associated with peripheral insulin resistance

T2 - In vivo MR imaging and spectroscopy studies

AU - Hwang, Jong Hee

AU - Stein, Daniel T.

AU - Barzilai, Nir

AU - Cui, Min-Hui

AU - Tonelli, Julia

AU - Kishore, Preeti

AU - Hawkins, Meredith A.

PY - 2007/12

Y1 - 2007/12

N2 - Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF), and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were 1) to simultaneously measure IMCL, IHTG, VF, and abdominal SF in the same nondiabetic individuals using noninvasive 1H-magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (R d) during euglycemic-hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG, and VF. There were significant inverse correlations between whole body Rd and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body Rd (r = -0.86, P < 0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.

AB - Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF), and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were 1) to simultaneously measure IMCL, IHTG, VF, and abdominal SF in the same nondiabetic individuals using noninvasive 1H-magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (R d) during euglycemic-hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG, and VF. There were significant inverse correlations between whole body Rd and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body Rd (r = -0.86, P < 0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.

KW - Adipokines

KW - In vivo magnetic resonance imaging and spectroscopy

KW - Leptin

KW - Muscle and visceral fat

UR - http://www.scopus.com/inward/record.url?scp=37149001609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37149001609&partnerID=8YFLogxK

U2 - 10.1152/ajpendo.00590.2006

DO - 10.1152/ajpendo.00590.2006

M3 - Article

C2 - 17911339

AN - SCOPUS:37149001609

VL - 293

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 6

ER -