Increased insulin responsiveness and insulin clearance in thyrotoxicosis

Nir Barzilai, P. Cohen, D. Barzilai, E. Karnieli

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The euglycemic insulin clamp technique was used to evaluate in vivo insulin action in thyrotoxicosis (TTX). Insulin was infused at 0.5, 3 and 10 mu/kg per min, and the steady-state glucose infusion rate was determined in five TTX patients with fasting hyperinsulinemia and five healthy subjects. TTX is accompanied by a significant increase in insulin responsiveness, clearance and basal insulin delivery rate. Therefore, insulin resistance in TTX does not reside at the postreceptor peripheral tissue level, but may be the consequence of increased hepatic glucose production.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalIsrael Journal of Medical Sciences
Volume21
Issue number9
StatePublished - 1985
Externally publishedYes

Fingerprint

Thyrotoxicosis
Insulin
Glucose
Glucose Clamp Technique
Hyperinsulinism
Clamping devices
Insulin Resistance
Fasting
Healthy Volunteers
Tissue
Liver

ASJC Scopus subject areas

  • Bioengineering
  • Medicine(all)

Cite this

Increased insulin responsiveness and insulin clearance in thyrotoxicosis. / Barzilai, Nir; Cohen, P.; Barzilai, D.; Karnieli, E.

In: Israel Journal of Medical Sciences, Vol. 21, No. 9, 1985, p. 722-726.

Research output: Contribution to journalArticle

Barzilai, N, Cohen, P, Barzilai, D & Karnieli, E 1985, 'Increased insulin responsiveness and insulin clearance in thyrotoxicosis', Israel Journal of Medical Sciences, vol. 21, no. 9, pp. 722-726.
Barzilai, Nir ; Cohen, P. ; Barzilai, D. ; Karnieli, E. / Increased insulin responsiveness and insulin clearance in thyrotoxicosis. In: Israel Journal of Medical Sciences. 1985 ; Vol. 21, No. 9. pp. 722-726.
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