Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

Kevin Kalinsky, Emerson A. Lim, Eleni Andreopoulou, Avni M. Desai, Zhezhen Jin, Yifan Tu, Hanina Hibshoosh, Antai Wang, Heather Greenlee, Katherine D. Crew, Matthew Maurer, Joseph A. Sparano, Dawn L. Hershman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalCancer Investigation
Volume32
Issue number9
DOIs
StatePublished - Nov 21 2014

Keywords

  • Breast cancer
  • Hispanic
  • Non-Hispanic white
  • Oncotype DX
  • Proliferation axis score
  • Tumor proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Kalinsky, K., Lim, E. A., Andreopoulou, E., Desai, A. M., Jin, Z., Tu, Y., Hibshoosh, H., Wang, A., Greenlee, H., Crew, K. D., Maurer, M., Sparano, J. A., & Hershman, D. L. (2014). Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. Cancer Investigation, 32(9), 439-444. https://doi.org/10.3109/07357907.2014.958232