Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

Kevin Kalinsky, Emerson A. Lim, Eleni Andreopoulou, Avni M. Desai, Zhezhen Jin, Yifan Tu, Hanina Hibshoosh, Antai Wang, Heather Greenlee, Katherine D. Crew, Matthew Maurer, Joseph A. Sparano, Dawn L. Hershman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalCancer Investigation
Volume32
Issue number9
DOIs
StatePublished - Nov 21 2014
Externally publishedYes

Fingerprint

Hispanic Americans
Breast Neoplasms
Genes
Neoplasms
Aurora Kinase A
Hormones
Recurrence
Mortality

Keywords

  • Breast cancer
  • Hispanic
  • Non-Hispanic white
  • Oncotype DX
  • Proliferation axis score
  • Tumor proliferation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Kalinsky, K., Lim, E. A., Andreopoulou, E., Desai, A. M., Jin, Z., Tu, Y., ... Hershman, D. L. (2014). Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. Cancer Investigation, 32(9), 439-444. https://doi.org/10.3109/07357907.2014.958232

Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. / Kalinsky, Kevin; Lim, Emerson A.; Andreopoulou, Eleni; Desai, Avni M.; Jin, Zhezhen; Tu, Yifan; Hibshoosh, Hanina; Wang, Antai; Greenlee, Heather; Crew, Katherine D.; Maurer, Matthew; Sparano, Joseph A.; Hershman, Dawn L.

In: Cancer Investigation, Vol. 32, No. 9, 21.11.2014, p. 439-444.

Research output: Contribution to journalArticle

Kalinsky, K, Lim, EA, Andreopoulou, E, Desai, AM, Jin, Z, Tu, Y, Hibshoosh, H, Wang, A, Greenlee, H, Crew, KD, Maurer, M, Sparano, JA & Hershman, DL 2014, 'Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer', Cancer Investigation, vol. 32, no. 9, pp. 439-444. https://doi.org/10.3109/07357907.2014.958232
Kalinsky, Kevin ; Lim, Emerson A. ; Andreopoulou, Eleni ; Desai, Avni M. ; Jin, Zhezhen ; Tu, Yifan ; Hibshoosh, Hanina ; Wang, Antai ; Greenlee, Heather ; Crew, Katherine D. ; Maurer, Matthew ; Sparano, Joseph A. ; Hershman, Dawn L. / Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. In: Cancer Investigation. 2014 ; Vol. 32, No. 9. pp. 439-444.
@article{68f8902e12684c67a03c69b03f17f037,
title = "Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer",
abstract = "Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.",
keywords = "Breast cancer, Hispanic, Non-Hispanic white, Oncotype DX, Proliferation axis score, Tumor proliferation",
author = "Kevin Kalinsky and Lim, {Emerson A.} and Eleni Andreopoulou and Desai, {Avni M.} and Zhezhen Jin and Yifan Tu and Hanina Hibshoosh and Antai Wang and Heather Greenlee and Crew, {Katherine D.} and Matthew Maurer and Sparano, {Joseph A.} and Hershman, {Dawn L.}",
year = "2014",
month = "11",
day = "21",
doi = "10.3109/07357907.2014.958232",
language = "English (US)",
volume = "32",
pages = "439--444",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "9",

}

TY - JOUR

T1 - Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

AU - Kalinsky, Kevin

AU - Lim, Emerson A.

AU - Andreopoulou, Eleni

AU - Desai, Avni M.

AU - Jin, Zhezhen

AU - Tu, Yifan

AU - Hibshoosh, Hanina

AU - Wang, Antai

AU - Greenlee, Heather

AU - Crew, Katherine D.

AU - Maurer, Matthew

AU - Sparano, Joseph A.

AU - Hershman, Dawn L.

PY - 2014/11/21

Y1 - 2014/11/21

N2 - Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

AB - Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

KW - Breast cancer

KW - Hispanic

KW - Non-Hispanic white

KW - Oncotype DX

KW - Proliferation axis score

KW - Tumor proliferation

UR - http://www.scopus.com/inward/record.url?scp=84911117895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911117895&partnerID=8YFLogxK

U2 - 10.3109/07357907.2014.958232

DO - 10.3109/07357907.2014.958232

M3 - Article

C2 - 25254601

AN - SCOPUS:84911117895

VL - 32

SP - 439

EP - 444

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 9

ER -