Increased deiodination of L-thyroxine and L-triiodothyronine by liver microsomes from rats treated with phenobarbital

H. L. Schwartz, V. Kozyreff, Martin I. Surks, J. H. Oppenheimer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PHENOBARBITAL given to rats in doses known to increase the formation of hepatic smooth endoplasmic reticulum (SER) and drug-metabolizing enzymes also increases hepatocellular binding of thyroxine (T4)1 and its deiodinative and biliary clearance2. Subcellular fractionation of liver homogenates suggested that the increased hepatocellular binding could be attributed to the microsomal membranes3. Because hepatic microsomes contain a specific iodothyronine deiodinase4-7, we attempted to determine whether the increased deiodination observed in vivo could be related to increased microsomal activity.

Original languageEnglish (US)
Pages (from-to)1262-1263
Number of pages2
JournalNature
Volume221
Issue number5187
DOIs
StatePublished - 1969
Externally publishedYes

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Triiodothyronine
Liver Microsomes
Phenobarbital
Thyroxine
Liver
Smooth Endoplasmic Reticulum
Microsomes
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Increased deiodination of L-thyroxine and L-triiodothyronine by liver microsomes from rats treated with phenobarbital. / Schwartz, H. L.; Kozyreff, V.; Surks, Martin I.; Oppenheimer, J. H.

In: Nature, Vol. 221, No. 5187, 1969, p. 1262-1263.

Research output: Contribution to journalArticle

Schwartz, H. L. ; Kozyreff, V. ; Surks, Martin I. ; Oppenheimer, J. H. / Increased deiodination of L-thyroxine and L-triiodothyronine by liver microsomes from rats treated with phenobarbital. In: Nature. 1969 ; Vol. 221, No. 5187. pp. 1262-1263.
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