PHENOBARBITAL given to rats in doses known to increase the formation of hepatic smooth endoplasmic reticulum (SER) and drug-metabolizing enzymes also increases hepatocellular binding of thyroxine (T4)1 and its deiodinative and biliary clearance2. Subcellular fractionation of liver homogenates suggested that the increased hepatocellular binding could be attributed to the microsomal membranes3. Because hepatic microsomes contain a specific iodothyronine deiodinase4-7, we attempted to determine whether the increased deiodination observed in vivo could be related to increased microsomal activity.
|Original language||English (US)|
|Number of pages||2|
|State||Published - 1969|
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