Increased circulating interleukin-7 levels in HIV-1-infected women

Laura A. Napolitano, Trevor D. Burt, Peter Bacchetti, Yolanda Barrón, Audrey L. French, Andrea Kovacs, Kathryn Anastos, Mary Young, Joseph M. McCune, Ruth M. Greenblatt

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Sex-based differences in CD4 T-cell (CD4) counts are well recognized, but the basis for these differences has not been identified. Conceivably, homeostatic factors may play a role in this process by regulating T-cell maintenance and repletion. Interleukin (IL)-7 is essential for normal T-cell production and homeostasis. We hypothesized that differences in IL-7 might contribute to sex-based differences in CD4 counts. Circulating IL-7 levels were analyzed in 299 HIV-1-infected women and men. Regression analysis estimated that IL-7 levels were 40% higher in women than in men (P = 0.0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume40
Issue number5
DOIs
StatePublished - Dec 2005

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Interleukin-7
HIV-1
CD4 Lymphocyte Count
T-Lymphocytes
Sex Characteristics
Homeostasis
Cell Count
Regression Analysis
Maintenance

Keywords

  • CD4-positive T cells
  • Cytokines
  • Interleukin-7
  • Sex differences
  • Sexual dimorphism

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Napolitano, L. A., Burt, T. D., Bacchetti, P., Barrón, Y., French, A. L., Kovacs, A., ... Greenblatt, R. M. (2005). Increased circulating interleukin-7 levels in HIV-1-infected women. Journal of Acquired Immune Deficiency Syndromes, 40(5), 581-584. https://doi.org/10.1097/01.qai.0000187442.53708.b4

Increased circulating interleukin-7 levels in HIV-1-infected women. / Napolitano, Laura A.; Burt, Trevor D.; Bacchetti, Peter; Barrón, Yolanda; French, Audrey L.; Kovacs, Andrea; Anastos, Kathryn; Young, Mary; McCune, Joseph M.; Greenblatt, Ruth M.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 40, No. 5, 12.2005, p. 581-584.

Research output: Contribution to journalArticle

Napolitano, LA, Burt, TD, Bacchetti, P, Barrón, Y, French, AL, Kovacs, A, Anastos, K, Young, M, McCune, JM & Greenblatt, RM 2005, 'Increased circulating interleukin-7 levels in HIV-1-infected women', Journal of Acquired Immune Deficiency Syndromes, vol. 40, no. 5, pp. 581-584. https://doi.org/10.1097/01.qai.0000187442.53708.b4
Napolitano, Laura A. ; Burt, Trevor D. ; Bacchetti, Peter ; Barrón, Yolanda ; French, Audrey L. ; Kovacs, Andrea ; Anastos, Kathryn ; Young, Mary ; McCune, Joseph M. ; Greenblatt, Ruth M. / Increased circulating interleukin-7 levels in HIV-1-infected women. In: Journal of Acquired Immune Deficiency Syndromes. 2005 ; Vol. 40, No. 5. pp. 581-584.
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