Increased circulating CSF-1 (M-CSF) in myeloproliferative disease: Association with myeloid metaplasia and peripheral bone marrow extension

H. S. Gilbert, V. Praloran, E. R. Stanley

Research output: Contribution to journalArticle

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Abstract

Myeloproliferative disease (MPD) is heterogeneous in phenotypic expression and may display features consistent with expansion and activation of the monocyte/macrophage population during its course. The role of colony-stimulating factor-1 (CSF-1) in the pathophysiology of MPD was investigated by measuring circulating CSF-1 levels and examining their relationship to disease phenotype. Serum CSF-1 concentrations, measured by radioimmunoassay, were elevated in all MPD phenotypes. CSF-1 levels diffed significantly between groups of patients with essential thrombocythemia, polycythemia vera, and postpolycythemic or agnogenic myeloid metaplasia (in ascending order). CSF-1 serum levels were positively correlated with spleen size and the degree of peripheral bone marrow extension, determined by scintigraphy using a macrophage-seeking isotope. There was no correlation between CSF-1 concentration and circulating levels of erythrocytes, neutrophils or platelets, or the presence of bone marrow fibrosis. Elevated serum CSF-1 levels appear to be associated with an expanded monocyte/macrophage population in MPD. In view of the known cooperativity between CSF-1 and other growth factors in regulating hematopoiesis, the finding of increased serum CSF-1 concentrations and its association with myeloid metaplasia and bone marrow extension may indicate a pathophysiologic role for CSF-1 in determining the phenotypic expression of MPD.

Original languageEnglish (US)
Pages (from-to)1231-1234
Number of pages4
JournalBlood
Volume74
Issue number4
StatePublished - 1989

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Primary Myelofibrosis
Macrophage Colony-Stimulating Factor
Bone
Bone Marrow
Macrophages
Serum
Monocytes
Phenotype
Essential Thrombocythemia
Polycythemia Vera
Macrophage Activation
Hematopoiesis
Platelets
Isotopes
Radionuclide Imaging
Population
Radioimmunoassay
Intercellular Signaling Peptides and Proteins
Neutrophils
Blood Platelets

ASJC Scopus subject areas

  • Hematology

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Increased circulating CSF-1 (M-CSF) in myeloproliferative disease : Association with myeloid metaplasia and peripheral bone marrow extension. / Gilbert, H. S.; Praloran, V.; Stanley, E. R.

In: Blood, Vol. 74, No. 4, 1989, p. 1231-1234.

Research output: Contribution to journalArticle

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