Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies

Anna Janowska-Wieczorek, Andrew R. Belch, Allan Jacobs, David Bowen, Rose Ann Padua, Elisabeth M. Paietta, E. Richard Stanley

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Recently, several malignant cell types have been reported to express colony-stimulating factor-1 (CSF-1) transcripts; however, the clinical significance of CSF-1 in malignancy has not been investigated. Using a CSF-1 radioimmunoassay, we surveyed concentrations of biologically active CSF-1 in the peripheral blood of 316 patients with malignant and premalignant hematologic disorders; 75 had a myelodysplastic syndrome (MDS), 12 acute myelogenous leukemia (AML), 7 chronic myelogenous leukemia, 21 chronic lymphocytic leukemia (CLL), 106 non-Hodgkin's lymphoma (NHL; of low-, intermediate-, and high-grade malignancy), 46 Hodgkin's disease (HD), 46 multiple myeloma (MM), and 3 monoclonal gammopathy of undetermined significance. Controls were 64 healthy subjects. The CSF-1 concentration was correlated with the type of disease, status of the disease, treatment status, and hematologic parameters. CSF-1 concentration was significantly elevated in 83.5% of the patients with active disease, and for each active disease group it was significantly greater (P < .0001) than in the control. Thus, the high circulating CSF-1 concentration was not associated with a particular malignant phenotype or MDS subtype, but did correlate with the disease activity of both NHL and HD, and the tumor burden in MM, AML, and CLL. There was no correlation of the CSF-1 level with total counts of monocytes or neutrophils in patients with MDS or other malignancies. The cellular basis for the elevated circulating CSF-1 was not investigated. However, the results are consistent with the possibility that the premalignant or malignant cells themselves produce CSF-1 or regulate its production by normal cells.

Original languageEnglish (US)
Pages (from-to)1796-1803
Number of pages8
JournalBlood
Volume77
Issue number8
StatePublished - Apr 15 1991
Externally publishedYes

Fingerprint

Preleukemia
Lymphoid Leukemia
Macrophage Colony-Stimulating Factor
Neoplasms
Myelodysplastic Syndromes
B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Hodgkin Disease
Acute Myeloid Leukemia
Monoclonal Gammopathy of Undetermined Significance
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumor Burden
Non-Hodgkin's Lymphoma
Radioimmunoassay
Tumors
Monocytes
Healthy Volunteers
Neutrophils
Blood

ASJC Scopus subject areas

  • Hematology

Cite this

Janowska-Wieczorek, A., Belch, A. R., Jacobs, A., Bowen, D., Padua, R. A., Paietta, E. M., & Stanley, E. R. (1991). Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies. Blood, 77(8), 1796-1803.

Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies. / Janowska-Wieczorek, Anna; Belch, Andrew R.; Jacobs, Allan; Bowen, David; Padua, Rose Ann; Paietta, Elisabeth M.; Stanley, E. Richard.

In: Blood, Vol. 77, No. 8, 15.04.1991, p. 1796-1803.

Research output: Contribution to journalArticle

Janowska-Wieczorek, A, Belch, AR, Jacobs, A, Bowen, D, Padua, RA, Paietta, EM & Stanley, ER 1991, 'Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies', Blood, vol. 77, no. 8, pp. 1796-1803.
Janowska-Wieczorek A, Belch AR, Jacobs A, Bowen D, Padua RA, Paietta EM et al. Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies. Blood. 1991 Apr 15;77(8):1796-1803.
Janowska-Wieczorek, Anna ; Belch, Andrew R. ; Jacobs, Allan ; Bowen, David ; Padua, Rose Ann ; Paietta, Elisabeth M. ; Stanley, E. Richard. / Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies. In: Blood. 1991 ; Vol. 77, No. 8. pp. 1796-1803.
@article{2b45110155184f68929136d215200eb2,
title = "Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies",
abstract = "Recently, several malignant cell types have been reported to express colony-stimulating factor-1 (CSF-1) transcripts; however, the clinical significance of CSF-1 in malignancy has not been investigated. Using a CSF-1 radioimmunoassay, we surveyed concentrations of biologically active CSF-1 in the peripheral blood of 316 patients with malignant and premalignant hematologic disorders; 75 had a myelodysplastic syndrome (MDS), 12 acute myelogenous leukemia (AML), 7 chronic myelogenous leukemia, 21 chronic lymphocytic leukemia (CLL), 106 non-Hodgkin's lymphoma (NHL; of low-, intermediate-, and high-grade malignancy), 46 Hodgkin's disease (HD), 46 multiple myeloma (MM), and 3 monoclonal gammopathy of undetermined significance. Controls were 64 healthy subjects. The CSF-1 concentration was correlated with the type of disease, status of the disease, treatment status, and hematologic parameters. CSF-1 concentration was significantly elevated in 83.5{\%} of the patients with active disease, and for each active disease group it was significantly greater (P < .0001) than in the control. Thus, the high circulating CSF-1 concentration was not associated with a particular malignant phenotype or MDS subtype, but did correlate with the disease activity of both NHL and HD, and the tumor burden in MM, AML, and CLL. There was no correlation of the CSF-1 level with total counts of monocytes or neutrophils in patients with MDS or other malignancies. The cellular basis for the elevated circulating CSF-1 was not investigated. However, the results are consistent with the possibility that the premalignant or malignant cells themselves produce CSF-1 or regulate its production by normal cells.",
author = "Anna Janowska-Wieczorek and Belch, {Andrew R.} and Allan Jacobs and David Bowen and Padua, {Rose Ann} and Paietta, {Elisabeth M.} and Stanley, {E. Richard}",
year = "1991",
month = "4",
day = "15",
language = "English (US)",
volume = "77",
pages = "1796--1803",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "8",

}

TY - JOUR

T1 - Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies

AU - Janowska-Wieczorek, Anna

AU - Belch, Andrew R.

AU - Jacobs, Allan

AU - Bowen, David

AU - Padua, Rose Ann

AU - Paietta, Elisabeth M.

AU - Stanley, E. Richard

PY - 1991/4/15

Y1 - 1991/4/15

N2 - Recently, several malignant cell types have been reported to express colony-stimulating factor-1 (CSF-1) transcripts; however, the clinical significance of CSF-1 in malignancy has not been investigated. Using a CSF-1 radioimmunoassay, we surveyed concentrations of biologically active CSF-1 in the peripheral blood of 316 patients with malignant and premalignant hematologic disorders; 75 had a myelodysplastic syndrome (MDS), 12 acute myelogenous leukemia (AML), 7 chronic myelogenous leukemia, 21 chronic lymphocytic leukemia (CLL), 106 non-Hodgkin's lymphoma (NHL; of low-, intermediate-, and high-grade malignancy), 46 Hodgkin's disease (HD), 46 multiple myeloma (MM), and 3 monoclonal gammopathy of undetermined significance. Controls were 64 healthy subjects. The CSF-1 concentration was correlated with the type of disease, status of the disease, treatment status, and hematologic parameters. CSF-1 concentration was significantly elevated in 83.5% of the patients with active disease, and for each active disease group it was significantly greater (P < .0001) than in the control. Thus, the high circulating CSF-1 concentration was not associated with a particular malignant phenotype or MDS subtype, but did correlate with the disease activity of both NHL and HD, and the tumor burden in MM, AML, and CLL. There was no correlation of the CSF-1 level with total counts of monocytes or neutrophils in patients with MDS or other malignancies. The cellular basis for the elevated circulating CSF-1 was not investigated. However, the results are consistent with the possibility that the premalignant or malignant cells themselves produce CSF-1 or regulate its production by normal cells.

AB - Recently, several malignant cell types have been reported to express colony-stimulating factor-1 (CSF-1) transcripts; however, the clinical significance of CSF-1 in malignancy has not been investigated. Using a CSF-1 radioimmunoassay, we surveyed concentrations of biologically active CSF-1 in the peripheral blood of 316 patients with malignant and premalignant hematologic disorders; 75 had a myelodysplastic syndrome (MDS), 12 acute myelogenous leukemia (AML), 7 chronic myelogenous leukemia, 21 chronic lymphocytic leukemia (CLL), 106 non-Hodgkin's lymphoma (NHL; of low-, intermediate-, and high-grade malignancy), 46 Hodgkin's disease (HD), 46 multiple myeloma (MM), and 3 monoclonal gammopathy of undetermined significance. Controls were 64 healthy subjects. The CSF-1 concentration was correlated with the type of disease, status of the disease, treatment status, and hematologic parameters. CSF-1 concentration was significantly elevated in 83.5% of the patients with active disease, and for each active disease group it was significantly greater (P < .0001) than in the control. Thus, the high circulating CSF-1 concentration was not associated with a particular malignant phenotype or MDS subtype, but did correlate with the disease activity of both NHL and HD, and the tumor burden in MM, AML, and CLL. There was no correlation of the CSF-1 level with total counts of monocytes or neutrophils in patients with MDS or other malignancies. The cellular basis for the elevated circulating CSF-1 was not investigated. However, the results are consistent with the possibility that the premalignant or malignant cells themselves produce CSF-1 or regulate its production by normal cells.

UR - http://www.scopus.com/inward/record.url?scp=0025727593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025727593&partnerID=8YFLogxK

M3 - Article

C2 - 2015402

AN - SCOPUS:0025727593

VL - 77

SP - 1796

EP - 1803

JO - Blood

JF - Blood

SN - 0006-4971

IS - 8

ER -