Increased cerebral blood flow during m-CPP exacerbation of obsessive-compulsive disorder

Eric Hollander, I. Prohovnik, D. J. Stein

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The partial serotonin agonist m-chlorophenylpiperazine (m-CPP) has been reported to increase obsessive-compulsive symptoms in some patients with obsessive-compulsive disorder (OCD). The authors investigated the underlying physiological mechanisms of this variable exacerbation by imaging regional cerebral blood flow with the planar xenon-133 method after administration of oral m-CPP (0.5 mg/kg). Seven patients who responded to m-CPP with symptomatic exacerbation had a marked increase in global cortical perfusion (18.1%), in contrast to the remaining 7 nonresponders to m-CPP, who showed no change. These results suggest that m-CPP exacerbation of OCD symptoms is associated with increased cortical blood flow.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume7
Issue number4
StatePublished - 1995
Externally publishedYes

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Cerebrovascular Circulation
Obsessive-Compulsive Disorder
Serotonin Receptor Agonists
Xenon
Regional Blood Flow
Oral Administration
Perfusion
1-(3-chlorophenyl)piperazine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Increased cerebral blood flow during m-CPP exacerbation of obsessive-compulsive disorder. / Hollander, Eric; Prohovnik, I.; Stein, D. J.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 7, No. 4, 1995, p. 485-490.

Research output: Contribution to journalArticle

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