Increased AβPP processing in familial danish dementia patients

Shuji Matsuda, Robert Tamayev, Luciano D'Adamio

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia (FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to the human disease. These mice carry one mutant and one wild type Bri2/Itm2b allele, like FDD patients. Analysis of FDD KI mice and samples from human patients has shown that the Danish mutation causes loss of Bri2 protein. FDD KI mice show synaptic plasticity and memory impairments. BRI2 is a physiological interactor of amyloid-β protein precursor (AβPP), a gene associated with Alzheimer's disease, which inhibits processing of AβPP. AβPP/Bri2 complexes are reduced in synaptic membranes of FDD KI mice. Consequently, AβPP metabolites derived from processing of AβPP by β-, α-, and γ-secretases are increased in Danish dementia mice. AβPP haplodeficiency prevents memory and synaptic dysfunctions, consistent with a role for AβPP-metabolites in the pathogenesis of memory and synaptic deficits. This genetic suppression provides compelling evidence that AβPP and BRI2 functionally interact. Here, we have investigated whether AβPP processing is altered in FDD patients' brain samples. We find that the levels of several AβPP metabolites, including Aβ, are significantly increased in the brain sample derived from an FDD patient. Our data are consistent with the findings in FDD KI mice, and support the hypothesis that the neurological effects of the Danish form of BRI2 are caused by toxic AβPP metabolites, suggesting that Familial Danish and Alzheimer's dementias share common pathogenic mechanisms.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalJournal of Alzheimer's Disease
Volume27
Issue number2
DOIs
StatePublished - 2011

Fingerprint

Amyloid beta-Protein Precursor
Alzheimer Disease
Familial Danish dementia
Genetic Suppression
Synaptic Membranes
Amyloid Precursor Protein Secretases
Mutation
Neuronal Plasticity
Poisons
Memory Disorders
Brain
Genes
Dementia
Alleles

Keywords

  • Alzheimer's disease
  • amyloid-β protein precursor
  • BRI2
  • familial danish dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Increased AβPP processing in familial danish dementia patients. / Matsuda, Shuji; Tamayev, Robert; D'Adamio, Luciano.

In: Journal of Alzheimer's Disease, Vol. 27, No. 2, 2011, p. 385-391.

Research output: Contribution to journalArticle

Matsuda, Shuji ; Tamayev, Robert ; D'Adamio, Luciano. / Increased AβPP processing in familial danish dementia patients. In: Journal of Alzheimer's Disease. 2011 ; Vol. 27, No. 2. pp. 385-391.
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