Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis

Dayvison F S Freitas, Suelen S. Santos, Rodrigo Almeida-Paes, Manoel M E De Oliveira, Antonio C F Do Valle, Maria Clara Gutierrez-Galhardo, Rosely M. Zancopé-Oliveira, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalVirulence
Volume6
Issue number2
DOIs
StatePublished - Feb 10 2015

Fingerprint

Sporothrix
Sporotrichosis
Virulence
Exudates and Transudates
Larva
Cats
Chronic Disease
Bone and Bones
Skin

Keywords

  • Brazil
  • Chitin synthase
  • Disseminated
  • Galleria mellonella
  • Reactive nitrogen intermediates
  • Rio de Janeiro
  • Sporothrix brasiliensis
  • Sporotrichosis
  • T3B PCR
  • Virulence

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Parasitology
  • Immunology
  • Microbiology (medical)

Cite this

Freitas, D. F. S., Santos, S. S., Almeida-Paes, R., De Oliveira, M. M. E., Do Valle, A. C. F., Gutierrez-Galhardo, M. C., ... Nosanchuk, J. D. (2015). Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence, 6(2), 112-120. https://doi.org/10.1080/21505594.2015.1014274

Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. / Freitas, Dayvison F S; Santos, Suelen S.; Almeida-Paes, Rodrigo; De Oliveira, Manoel M E; Do Valle, Antonio C F; Gutierrez-Galhardo, Maria Clara; Zancopé-Oliveira, Rosely M.; Nosanchuk, Joshua D.

In: Virulence, Vol. 6, No. 2, 10.02.2015, p. 112-120.

Research output: Contribution to journalArticle

Freitas, DFS, Santos, SS, Almeida-Paes, R, De Oliveira, MME, Do Valle, ACF, Gutierrez-Galhardo, MC, Zancopé-Oliveira, RM & Nosanchuk, JD 2015, 'Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis', Virulence, vol. 6, no. 2, pp. 112-120. https://doi.org/10.1080/21505594.2015.1014274
Freitas DFS, Santos SS, Almeida-Paes R, De Oliveira MME, Do Valle ACF, Gutierrez-Galhardo MC et al. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence. 2015 Feb 10;6(2):112-120. https://doi.org/10.1080/21505594.2015.1014274
Freitas, Dayvison F S ; Santos, Suelen S. ; Almeida-Paes, Rodrigo ; De Oliveira, Manoel M E ; Do Valle, Antonio C F ; Gutierrez-Galhardo, Maria Clara ; Zancopé-Oliveira, Rosely M. ; Nosanchuk, Joshua D. / Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. In: Virulence. 2015 ; Vol. 6, No. 2. pp. 112-120.
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