Increase in 3-methylhistidine in umbilical cord blood from acidotic fetuses

David Garry, Tolga Kokturk, Reinaldo Figueroa, Dev Maulik, Saul R. Powell

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To examine the hypothesis that acidotic fetuses at birth have an increased catabolic state characterized by a negative nitrogen balance. STUDY DESIGN: Umbilical cord blood samples were obtained from a random, prospective series of fetuses at birth. Acidotic samples (pH<7.20) were matched with normals (pH≥7.20) according to maternal and gestational age. 3-Methylhistidine was analyzed in order to assess catabolic breakdown of muscle protein. RESULTS: 3-Methylhistidine was significantly increased (P <.05) in cord blood from acidotic fetuses when compared with controls and correlated negatively (P <.05) with umbilical arterial pH. CONCLUSION: Umbilical cord blood 3-methylhistidine may be used to assess fetal nitrogen balance; acidotic fetuses have increased muscle catabolism.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume47
Issue number8
StatePublished - Aug 2002
Externally publishedYes

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Fetal Blood
Fetus
Nitrogen
Parturition
Umbilicus
Muscle Proteins
Maternal Age
Gestational Age
Muscles
3-methylhistidine

Keywords

  • Acidosis
  • Methylhistines
  • Neonate
  • Umbilical cord

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Increase in 3-methylhistidine in umbilical cord blood from acidotic fetuses. / Garry, David; Kokturk, Tolga; Figueroa, Reinaldo; Maulik, Dev; Powell, Saul R.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 47, No. 8, 08.2002, p. 675-678.

Research output: Contribution to journalArticle

Garry, D, Kokturk, T, Figueroa, R, Maulik, D & Powell, SR 2002, 'Increase in 3-methylhistidine in umbilical cord blood from acidotic fetuses', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 47, no. 8, pp. 675-678.
Garry, David ; Kokturk, Tolga ; Figueroa, Reinaldo ; Maulik, Dev ; Powell, Saul R. / Increase in 3-methylhistidine in umbilical cord blood from acidotic fetuses. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2002 ; Vol. 47, No. 8. pp. 675-678.
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