Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in bcr, immunoglobulin, and t-cell receptor gene-rearrangement studies

Blythe H. Devlin, Howard Ratech, Russel Kaufman

Research output: Contribution to journalArticle

3 Scopus citations


Molecular analyses to determine clonality of T and B cells in malignant lymphoma and leukemia and to detect the (9;22) translocation in chronic myelogenous leukemia are commonly used in clinical molecular biology laboratories. We describe the inclusion of a sensitivity control in each of these assays derived from DNA of well-characterized cell lines. The inclusion of such a sample adds an important quality-control parameter to ensure assay-to-assay reproducibility and to satisfy accreditation and regulatory requirements.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalDiagnostic Molecular Pathology
Issue number4
Publication statusPublished - Dec 1994



  • Clonality
  • Gene rearrangements
  • Internal control
  • Molecular diagnosis
  • Southern blot

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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