TY - JOUR
T1 - Incidental non-Hodgkin's lymphoma in patients with localized prostate cancer
AU - Eisenberger, Claus F.
AU - Walsh, Patrick C.
AU - Eisenberger, Mario A.
AU - Chow, Nan Haw
AU - Partin, Alan W.
AU - Mostwin, Jacek L.
AU - Marshall, Fray F.
AU - Epstein, Jonathan I.
AU - Schoenberg, Mark
PY - 1999/1
Y1 - 1999/1
N2 - Objectives. To determine the outcome of patients with clinically organ- confined prostate cancer undergoing radical retropubic prostatectomy for cure and incidentally discovered concurrent low-grade non-Hodgkin's lymphoma at time of surgery. Methods. From September 1986 to September 1997, 4319 patients underwent radical retropubic prostatectomy at our institution. The records of 10 patients incidentally diagnosed to have low-grade non-Hodgkin's lymphoma at the time of radical prostatectomy were retrospectively reviewed. Results. Of 4319 patients requiring radical prostatectomy, 10 (0.2%) were found to have low-grade non-Hodgkin's lymphoma. All 10 men had an uneventful postoperative course. Two patients subsequently developed progression of lymphoma, one of whom required treatment. One patient died of sepsis associated with his lymphoma and 1 patient died of an unrelated malignancy (lung cancer), both 7 years following surgery. Two patients developed biochemical prostate-specific antigen recurrence. The remainder of men were free of prostate Cancer recurrence and experienced no progression of lymphoma at an average of 45 months (range 12 to 142). Conclusions. Patients with organ-confined prostate cancer, who are candidates for radical prostatectomy, experience long-term prostate cancer-free survival in the face of incidentally diagnosed low-grade lymphoma. Because the management of most incidentally discovered low-grade lymphomas is expectant, patients discovered at surgery to have this clinical entity should not be denied radical prostatectomy.
AB - Objectives. To determine the outcome of patients with clinically organ- confined prostate cancer undergoing radical retropubic prostatectomy for cure and incidentally discovered concurrent low-grade non-Hodgkin's lymphoma at time of surgery. Methods. From September 1986 to September 1997, 4319 patients underwent radical retropubic prostatectomy at our institution. The records of 10 patients incidentally diagnosed to have low-grade non-Hodgkin's lymphoma at the time of radical prostatectomy were retrospectively reviewed. Results. Of 4319 patients requiring radical prostatectomy, 10 (0.2%) were found to have low-grade non-Hodgkin's lymphoma. All 10 men had an uneventful postoperative course. Two patients subsequently developed progression of lymphoma, one of whom required treatment. One patient died of sepsis associated with his lymphoma and 1 patient died of an unrelated malignancy (lung cancer), both 7 years following surgery. Two patients developed biochemical prostate-specific antigen recurrence. The remainder of men were free of prostate Cancer recurrence and experienced no progression of lymphoma at an average of 45 months (range 12 to 142). Conclusions. Patients with organ-confined prostate cancer, who are candidates for radical prostatectomy, experience long-term prostate cancer-free survival in the face of incidentally diagnosed low-grade lymphoma. Because the management of most incidentally discovered low-grade lymphomas is expectant, patients discovered at surgery to have this clinical entity should not be denied radical prostatectomy.
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U2 - 10.1016/S0090-4295(98)00422-1
DO - 10.1016/S0090-4295(98)00422-1
M3 - Article
C2 - 9886608
AN - SCOPUS:0032905694
SN - 0090-4295
VL - 53
SP - 175
EP - 179
JO - Urology
JF - Urology
IS - 1
ER -