Incidence of cervical precancers among HIV-seropositive women

L. Stewart Massad, Xianhong Xie, Gypsyamber D'Souza, Teresa M. Darragh, Howard Minkoff, Rodney L. Wright, Christine Colie, Lorraine Sanchez-Keeland, Howard Strickler

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

OBJECTIVE: The objective of the study was to estimate the impact of human immunodeficiency virus (HIV) infection on the incidence of high-grade cervical intraepithelial neoplasia (CIN).

CONCLUSION: Although HIV-seropositive women have more CIN3+ than HIV-seronegative women, CIN3+ is uncommon and becomes even less frequent after the initiation of regular cervical screening.

RESULTS: CIN3+ was diagnosed in 139 HIV-seropositive (5%) and 19 HIV-seronegative women (2%) (P

STUDY DESIGN: HIV-seropositive and comparison seronegative women enrolled in a prospective US cohort study were followed up with semiannual Papanicolaou testing, with colposcopy for any abnormality. Histology results were retrieved to identify CIN3+ (CIN3, adenocarcinoma in situ, and cancer) and CIN2+ (CIN2 and CIN3+). Annual detection rates were calculated and risks compared using a Cox analysis. Median follow-up (interquartile range) was 11.0 (5.4-17.2) years for HIV-seronegative and 9.9 (2.5-16.0) for HIV-seropositive women.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume212
Issue number5
DOIs
StatePublished - May 1 2015

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HIV
Incidence
Colposcopy
Cervical Intraepithelial Neoplasia
Virus Diseases
Histology
Cohort Studies
Neoplasms

Keywords

  • cervical cancer prevention
  • cervical intraepithelial neoplasia
  • human immunodeficiency virus in women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence of cervical precancers among HIV-seropositive women. / Stewart Massad, L.; Xie, Xianhong; D'Souza, Gypsyamber; Darragh, Teresa M.; Minkoff, Howard; Wright, Rodney L.; Colie, Christine; Sanchez-Keeland, Lorraine; Strickler, Howard.

In: American Journal of Obstetrics and Gynecology, Vol. 212, No. 5, 01.05.2015.

Research output: Contribution to journalArticle

Stewart Massad, L. ; Xie, Xianhong ; D'Souza, Gypsyamber ; Darragh, Teresa M. ; Minkoff, Howard ; Wright, Rodney L. ; Colie, Christine ; Sanchez-Keeland, Lorraine ; Strickler, Howard. / Incidence of cervical precancers among HIV-seropositive women. In: American Journal of Obstetrics and Gynecology. 2015 ; Vol. 212, No. 5.
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