Incidence of and risk factors for genital human papillomavirus infection in women drug users

Deepti Dev, Yungtai Lo, Gloria Y F Ho, Robert D. Burk, Robert S. Klein

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A total of 230 women drug users were prospectively studied. At 6-month intervals, interviews, HIV testing, and cervicovaginal lavage sampling for human papillomavirus (HPV) were performed. HPV was detected and typed using a MY09/MY11 polymerase chain reaction system. 230 women without high-risk HPV (types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82), with or without non-high risk HPV types at baseline, were included in analyses. Incidence rates of and factors associated with HPV infections of all types and high-risk types (types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82) were analyzed. Baseline median age was 40 years (range 24-65); 62% of women were Hispanic, 20% black, and 16% white; 54 (24%) were HIV seropositive; 172 (75%) were without detectable HPV; 58 (25%) had only low-risk or untypeable HPV. The incidence rates for any and for high-risk type HPV infection were 9.5/100 and 4.8/100 person-years, respectively. HIV-positive women had a significantly increased hazard rate for any HPV (HRadj: 3.4; 95% CI: 1.4 to 8.0) and for high-risk HPV (HRadj 3.0; 95% CI: 1.4 to 6.6), adjusted for race, sexual behaviors, condom use, and history of other sexually transmitted infections. HIV infection was independently associated with a substantial and significantly increased risk for any and for high-risk genital HPV infection and was the most important risk factor found.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes
Volume41
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Papillomavirus Infections
Drug Users
Incidence
HIV
Human papillomavirus 18
Human papillomavirus 16
Therapeutic Irrigation
Condoms
Sexually Transmitted Diseases
Hispanic Americans
Sexual Behavior
HIV Infections
Interviews
Polymerase Chain Reaction

Keywords

  • Drug users
  • Human papillomavirus
  • Women

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Incidence of and risk factors for genital human papillomavirus infection in women drug users. / Dev, Deepti; Lo, Yungtai; Ho, Gloria Y F; Burk, Robert D.; Klein, Robert S.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 41, No. 4, 04.2006, p. 527-529.

Research output: Contribution to journalArticle

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abstract = "A total of 230 women drug users were prospectively studied. At 6-month intervals, interviews, HIV testing, and cervicovaginal lavage sampling for human papillomavirus (HPV) were performed. HPV was detected and typed using a MY09/MY11 polymerase chain reaction system. 230 women without high-risk HPV (types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82), with or without non-high risk HPV types at baseline, were included in analyses. Incidence rates of and factors associated with HPV infections of all types and high-risk types (types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82) were analyzed. Baseline median age was 40 years (range 24-65); 62{\%} of women were Hispanic, 20{\%} black, and 16{\%} white; 54 (24{\%}) were HIV seropositive; 172 (75{\%}) were without detectable HPV; 58 (25{\%}) had only low-risk or untypeable HPV. The incidence rates for any and for high-risk type HPV infection were 9.5/100 and 4.8/100 person-years, respectively. HIV-positive women had a significantly increased hazard rate for any HPV (HRadj: 3.4; 95{\%} CI: 1.4 to 8.0) and for high-risk HPV (HRadj 3.0; 95{\%} CI: 1.4 to 6.6), adjusted for race, sexual behaviors, condom use, and history of other sexually transmitted infections. HIV infection was independently associated with a substantial and significantly increased risk for any and for high-risk genital HPV infection and was the most important risk factor found.",
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