Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010

North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.

Original languageEnglish (US)
Pages (from-to)862-872
Number of pages11
JournalJournal of Infectious Diseases
Volume214
Issue number6
DOIs
StatePublished - Sep 15 2016
Externally publishedYes

Fingerprint

Opportunistic Infections
Canada
Acquired Immunodeficiency Syndrome
HIV
Incidence
Observation
Research Design
Mycobacterium kansasii
Pneumocystis carinii
Mycobacterium avium Complex
Mycobacterium Infections
Pneumocystis Pneumonia
Candidiasis
Patient Care
Confidence Intervals

Keywords

  • AIDS-related opportunistic infections
  • CD4 T-lymphocyte count
  • combination antiretroviral therapy
  • epidemiology
  • HIV cohort studies
  • incidence
  • prophylaxis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. / North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA.

In: Journal of Infectious Diseases, Vol. 214, No. 6, 15.09.2016, p. 862-872.

Research output: Contribution to journalArticle

North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA. / Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. In: Journal of Infectious Diseases. 2016 ; Vol. 214, No. 6. pp. 862-872.
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abstract = "Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21{\%}) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, {"}person-years{"}) with 95{\%} confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9{\%}) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.",
keywords = "AIDS-related opportunistic infections, CD4 T-lymphocyte count, combination antiretroviral therapy, epidemiology, HIV cohort studies, incidence, prophylaxis",
author = "{North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA} and Kate Buchacz and Bryan Lau and Yuezhou Jing and Ronald Bosch and Abraham, {Alison G.} and Gill, {M. John} and Silverberg, {Michael J.} and Goedert, {James J.} and Sterling, {Timothy R.} and Althoff, {Keri N.} and Martin, {Jeffrey N.} and Greer Burkholder and Neel Gandhi and Hasina Samji and Pragna Patel and Anita Rachlis and Thorne, {Jennifer E.} and Sonia Napravnik and Keith Henry and Angel Mayor and Kelly Gebo and Gange, {Stephen J.} and Moore, {Richard D.} and Brooks, {John T.} and Kirk, {Gregory D.} and Benson, {Constance A.} and Bosch, {Ronald J.} and Stephen Boswell and Mayer, {Kenneth H.} and Chris Grasso and Hogg, {Robert S.} and Harrigan, {P. Richard} and Montaner, {Julio S G} and Angela Cescon and Gebo, {Kelly A.} and Carey, {John T.} and Benigno Rodriguez and Horberg, {Michael A.} and Jacobson, {Lisa P.} and Gypsyamber D'Souza and Klein, {Marina B.} and Rourke, {Sean B.} and Burchell, {Ann N.} and Rachlis, {Anita R.} and Hunter-Mellado, {Robert F.} and Mayor, {Angel M.} and Deeks, {Steven G.} and Saag, {Michael S.} and Mugavero, {Michael J.} and Kathryn Anastos",
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TY - JOUR

T1 - Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010

AU - North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA

AU - Buchacz, Kate

AU - Lau, Bryan

AU - Jing, Yuezhou

AU - Bosch, Ronald

AU - Abraham, Alison G.

AU - Gill, M. John

AU - Silverberg, Michael J.

AU - Goedert, James J.

AU - Sterling, Timothy R.

AU - Althoff, Keri N.

AU - Martin, Jeffrey N.

AU - Burkholder, Greer

AU - Gandhi, Neel

AU - Samji, Hasina

AU - Patel, Pragna

AU - Rachlis, Anita

AU - Thorne, Jennifer E.

AU - Napravnik, Sonia

AU - Henry, Keith

AU - Mayor, Angel

AU - Gebo, Kelly

AU - Gange, Stephen J.

AU - Moore, Richard D.

AU - Brooks, John T.

AU - Kirk, Gregory D.

AU - Benson, Constance A.

AU - Bosch, Ronald J.

AU - Boswell, Stephen

AU - Mayer, Kenneth H.

AU - Grasso, Chris

AU - Hogg, Robert S.

AU - Harrigan, P. Richard

AU - Montaner, Julio S G

AU - Cescon, Angela

AU - Gebo, Kelly A.

AU - Carey, John T.

AU - Rodriguez, Benigno

AU - Horberg, Michael A.

AU - Jacobson, Lisa P.

AU - D'Souza, Gypsyamber

AU - Klein, Marina B.

AU - Rourke, Sean B.

AU - Burchell, Ann N.

AU - Rachlis, Anita R.

AU - Hunter-Mellado, Robert F.

AU - Mayor, Angel M.

AU - Deeks, Steven G.

AU - Saag, Michael S.

AU - Mugavero, Michael J.

AU - Anastos, Kathryn

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.

AB - Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.

KW - AIDS-related opportunistic infections

KW - CD4 T-lymphocyte count

KW - combination antiretroviral therapy

KW - epidemiology

KW - HIV cohort studies

KW - incidence

KW - prophylaxis

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U2 - 10.1093/infdis/jiw085

DO - 10.1093/infdis/jiw085

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C2 - 27559122

AN - SCOPUS:84985036608

VL - 214

SP - 862

EP - 872

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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