TY - JOUR
T1 - Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010
AU - North American Aids Cohort Collaboration On Research And Design (na-Accord) Of IeDEA
AU - Buchacz, Kate
AU - Lau, Bryan
AU - Jing, Yuezhou
AU - Bosch, Ronald
AU - Abraham, Alison G.
AU - Gill, M. John
AU - Silverberg, Michael J.
AU - Goedert, James J.
AU - Sterling, Timothy R.
AU - Althoff, Keri N.
AU - Martin, Jeffrey N.
AU - Burkholder, Greer
AU - Gandhi, Neel
AU - Samji, Hasina
AU - Patel, Pragna
AU - Rachlis, Anita
AU - Thorne, Jennifer E.
AU - Napravnik, Sonia
AU - Henry, Keith
AU - Mayor, Angel
AU - Gebo, Kelly
AU - Gange, Stephen J.
AU - Moore, Richard D.
AU - Brooks, John T.
AU - Kirk, Gregory D.
AU - Benson, Constance A.
AU - Bosch, Ronald J.
AU - Boswell, Stephen
AU - Mayer, Kenneth H.
AU - Grasso, Chris
AU - Hogg, Robert S.
AU - Harrigan, P. Richard
AU - Montaner, Julio S.G.
AU - Cescon, Angela
AU - Carey, John T.
AU - Rodriguez, Benigno
AU - Horberg, Michael A.
AU - Jacobson, Lisa P.
AU - D'Souza, Gypsyamber
AU - Klein, Marina B.
AU - Rourke, Sean B.
AU - Burchell, Ann N.
AU - Rachlis, Anita R.
AU - Hunter-Mellado, Robert F.
AU - Mayor, Angel M.
AU - Deeks, Steven G.
AU - Saag, Michael S.
AU - Mugavero, Michael J.
AU - Willig, James
AU - Anastos, Kathryn
N1 - Publisher Copyright:
© 2016 Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.
AB - Background. There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. Methods. We studiedHIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010. Results. A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection. Conclusions. For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.
KW - AIDS-related opportunistic infections
KW - CD4 T-lymphocyte count
KW - HIV cohort studies
KW - combination antiretroviral therapy
KW - epidemiology
KW - incidence
KW - prophylaxis
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U2 - 10.1093/infdis/jiw085
DO - 10.1093/infdis/jiw085
M3 - Article
C2 - 27559122
AN - SCOPUS:84985036608
SN - 0022-1899
VL - 214
SP - 862
EP - 872
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -