Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey

Christian Stapf, Daniel L. Labovitz, Robert R. Sciacca, Henning Mast, Jay P. Mohr, Ralph L. Sacco

Research output: Contribution to journalArticle

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Abstract

Background: Brain arteriovenous malformations (AVMs) represent a potential source of intracranial hemorrhage, especially in young adults, but prospective population-based incidence data on AVM hemorrhage are lacking. We investigated the incidence of first-ever AVM hemorrhage in adults based on population data from the Northern Manhattan Stroke Study (NOMASS). Methods: NOMASS is a prospective, population-based, stroke incidence survey collecting all hospitalized and nonhospitalized cases with first-ever (incident) stroke over the age of 20 in a ZIP code-defined area. All patients undergo CT and/or MR brain imaging and clinical data are systematically collected from the medical records. For this study, data on all cases with incident intracranial hemorrhage, i.e. any intracerebral, intraventricular and/or subarachnoid hemorrhage, occurring between July 1, 1993 and June 30, 1997 were used. Patients with intracranial hemorrhage due to trauma, tumor or intracranial vascular malformations other than a previously unknown AVM were excluded from the study. Results: Of the 207 patients diagnosed with a first-ever intracranial hemorrhage, 3 cases (1.4%) with an underlying brain AVM were identified. The crude incidence rate for first-ever AVM hemorrhage in our adult population was 0.55 per 100,000 person-years (95% confidence interval 0.11-1.61). Conclusions: Our results support prior findings from retrospective surveys. Population-based studies providing a prospective design for AVM detection and diagnosis are needed to confirm the data.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalCerebrovascular Diseases
Volume13
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Arteriovenous Malformations
Stroke
Hemorrhage
Intracranial Hemorrhages
Incidence
Brain
Population
Vascular Malformations
Cerebral Hemorrhage
Subarachnoid Hemorrhage
Surveys and Questionnaires
Neuroimaging
Medical Records
Young Adult
Confidence Intervals
Wounds and Injuries
Neoplasms

Keywords

  • Cerebral arteriovenous malformations
  • Cerebral hemorrhage
  • Epidemiology

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. / Stapf, Christian; Labovitz, Daniel L.; Sciacca, Robert R.; Mast, Henning; Mohr, Jay P.; Sacco, Ralph L.

In: Cerebrovascular Diseases, Vol. 13, No. 1, 2002, p. 43-46.

Research output: Contribution to journalArticle

Stapf, Christian ; Labovitz, Daniel L. ; Sciacca, Robert R. ; Mast, Henning ; Mohr, Jay P. ; Sacco, Ralph L. / Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. In: Cerebrovascular Diseases. 2002 ; Vol. 13, No. 1. pp. 43-46.
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abstract = "Background: Brain arteriovenous malformations (AVMs) represent a potential source of intracranial hemorrhage, especially in young adults, but prospective population-based incidence data on AVM hemorrhage are lacking. We investigated the incidence of first-ever AVM hemorrhage in adults based on population data from the Northern Manhattan Stroke Study (NOMASS). Methods: NOMASS is a prospective, population-based, stroke incidence survey collecting all hospitalized and nonhospitalized cases with first-ever (incident) stroke over the age of 20 in a ZIP code-defined area. All patients undergo CT and/or MR brain imaging and clinical data are systematically collected from the medical records. For this study, data on all cases with incident intracranial hemorrhage, i.e. any intracerebral, intraventricular and/or subarachnoid hemorrhage, occurring between July 1, 1993 and June 30, 1997 were used. Patients with intracranial hemorrhage due to trauma, tumor or intracranial vascular malformations other than a previously unknown AVM were excluded from the study. Results: Of the 207 patients diagnosed with a first-ever intracranial hemorrhage, 3 cases (1.4{\%}) with an underlying brain AVM were identified. The crude incidence rate for first-ever AVM hemorrhage in our adult population was 0.55 per 100,000 person-years (95{\%} confidence interval 0.11-1.61). Conclusions: Our results support prior findings from retrospective surveys. Population-based studies providing a prospective design for AVM detection and diagnosis are needed to confirm the data.",
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