In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays

T. Douglas Mast; Peter G. Barthe; Inder Raj S. Makin; Michael H. Slayton; Chandra Priya Karunakaran; Mark T. Burgess; Amel Alqadah; Joseph F. Buell; Steven M. Rudich

doi:10.1109/ULTSYM.2009.5441425

In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays

T. Douglas Mast, Peter G. Barthe, Inder Raj S. Makin, Michael H. Slayton, Chandra Priya Karunakaran, Mark T. Burgess, Amel Alqadah, Joseph F. Buell, Steven M. Rudich

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3x20 mm ² aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of >747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.

Original language	English (US)
Title of host publication	2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	61-64
Number of pages	4
ISBN (Print)	9781424443895
DOIs	https://doi.org/10.1109/ULTSYM.2009.5441425
State	Published - 2009
Externally published	Yes
Event	2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy Duration: Sep 20 2009 → Sep 23 2009

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
ISSN (Print)	1051-0117

Conference

Conference	2009 IEEE International Ultrasonics Symposium, IUS 2009
Country/Territory	Italy
City	Rome
Period	9/20/09 → 9/23/09

ASJC Scopus subject areas

Acoustics and Ultrasonics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/ULTSYM.2009.5441425

Cite this

Mast, T. D., Barthe, P. G., Makin, I. R. S., Slayton, M. H., Karunakaran, C. P., Burgess, M. T., Alqadah, A., Buell, J. F., & Rudich, S. M. (2009). In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009 (pp. 61-64). Article 5441425 (Proceedings - IEEE Ultrasonics Symposium). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2009.5441425

In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays. / Mast, T. Douglas; Barthe, Peter G.; Makin, Inder Raj S. et al.
2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. Institute of Electrical and Electronics Engineers Inc., 2009. p. 61-64 5441425 (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mast, TD, Barthe, PG, Makin, IRS, Slayton, MH, Karunakaran, CP, Burgess, MT, Alqadah, A, Buell, JF & Rudich, SM 2009, In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays. in 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009., 5441425, Proceedings - IEEE Ultrasonics Symposium, Institute of Electrical and Electronics Engineers Inc., pp. 61-64, 2009 IEEE International Ultrasonics Symposium, IUS 2009, Rome, Italy, 9/20/09. https://doi.org/10.1109/ULTSYM.2009.5441425

Mast TD, Barthe PG, Makin IRS, Slayton MH, Karunakaran CP, Burgess MT et al. In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. Institute of Electrical and Electronics Engineers Inc. 2009. p. 61-64. 5441425. (Proceedings - IEEE Ultrasonics Symposium). doi: 10.1109/ULTSYM.2009.5441425

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title = "In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays",

abstract = "In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3x20 mm 2 aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of >747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.",

author = "Mast, {T. Douglas} and Barthe, {Peter G.} and Makin, {Inder Raj S.} and Slayton, {Michael H.} and Karunakaran, {Chandra Priya} and Burgess, {Mark T.} and Amel Alqadah and Buell, {Joseph F.} and Rudich, {Steven M.}",

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doi = "10.1109/ULTSYM.2009.5441425",

language = "English (US)",

isbn = "9781424443895",

series = "Proceedings - IEEE Ultrasonics Symposium",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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AB - In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3x20 mm 2 aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of >747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.

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In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays

Abstract

Publication series

Conference

ASJC Scopus subject areas

UN SDGs

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