In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays

T. Douglas Mast, Peter G. Barthe, Inder Raj S. Makin, Michael H. Slayton, Chandra Priya Karunakaran, Mark T. Burgess, Amel Alqadah, Joseph F. Buell, Steven M. Rudich

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3x20 mm 2 aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of >747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages61-64
Number of pages4
ISBN (Print)9781424443895
DOIs
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Conference

Conference2009 IEEE International Ultrasonics Symposium, IUS 2009
CountryItaly
CityRome
Period9/20/099/23/09

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Mast, T. D., Barthe, P. G., Makin, I. R. S., Slayton, M. H., Karunakaran, C. P., Burgess, M. T., Alqadah, A., Buell, J. F., & Rudich, S. M. (2009). In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009 (pp. 61-64). [5441425] (Proceedings - IEEE Ultrasonics Symposium). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2009.5441425