In the studies reported here, the ability of echo decorrelation imaging to predict thermal ablation in vivo is tested. Radiofrequency ablation (RFA) was performed on a normal swine liver (N=5) and ultrasound ablation using image-ablate arrays was performed on a rabbit implanted with VX2 tumors (N=3). Echo decorrelation imaging was able to predict ablation and overtreatment with high accuracy for both RFA and ultrasound ablation. The effect of tissue motion was studied by comparing the mean cumulative decorrelation with and without treatment. The mean cumulative decorrelation with treatment was found to be significantly greater than the mean cumulative decorrelation without treatment (p=0.0347 for RFA, p=0.024 for ultrasound ablation). The accuracy of ablation predictions was tested using receiver operating characteristic curves and the area under the ROC curve (AUROC) was significant for ablation and overtreatment for RFA (N=5). However, the AUROC was significant for only detecting ablation for the ultrasound ablation experiments (N=2).