In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism

Silvia Bernardi, Evdokia Anagnostou, Jun Shen, Alexander Kolevzon, Joseph D. Buxbaum, Eric Hollander, Patrick R. Hof, Jin Fan

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Attentional dysfunction is one of the most consistent findings in individuals with autism spectrum disorders (ASD). However, the significance of such findings for the pathophysiology of autism is unclear. In this study, we investigated cellular neurochemistry with proton magnetic resonance spectroscopy imaging (1H-MRS) in brain regions associated with networks subserving alerting, orienting, and executive control of attention in patients with ASD. Concentrations of cerebral N-acetyl-aspartate (NAA), creatinine + phosphocreatinine, choline-containing compounds, myo-inositol (Ins) and glutamate + glutamine (Glx) were determined by 3 T 1H-MRS examinations in 14 high-functioning medication-free adults with a diagnosis of ASD and 14 age- and IQ-matched healthy controls (HC) in the anterior cingulate cortex (ACC), thalamus, temporoparietal junction (TPJ), and areas near or along the intraparietal sulcus (IPS). Compared to HC group, the ASD group showed significantly lower Glx concentration in right ACC and reduced Ins concentration in left TPJ. This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalBrain Research
Volume1380
DOIs
StatePublished - Mar 22 2011

Fingerprint

Autistic Disorder
Magnetic Resonance Spectroscopy
Gyrus Cinguli
Executive Function
Inositol
Neurochemistry
Parietal Lobe
Choline
Glutamine
Thalamus
Synaptic Transmission
Glutamic Acid
Creatinine
Magnetic Resonance Imaging
Autism Spectrum Disorder
Control Groups
Brain
Proton Magnetic Resonance Spectroscopy

Keywords

  • Anterior cingulate cortex
  • Autism
  • Glutamate
  • Myo-inositol
  • Spectroscopy
  • Temporoparietal junction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Bernardi, S., Anagnostou, E., Shen, J., Kolevzon, A., Buxbaum, J. D., Hollander, E., ... Fan, J. (2011). In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism. Brain Research, 1380, 198-205. https://doi.org/10.1016/j.brainres.2010.12.057

In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism. / Bernardi, Silvia; Anagnostou, Evdokia; Shen, Jun; Kolevzon, Alexander; Buxbaum, Joseph D.; Hollander, Eric; Hof, Patrick R.; Fan, Jin.

In: Brain Research, Vol. 1380, 22.03.2011, p. 198-205.

Research output: Contribution to journalArticle

Bernardi, S, Anagnostou, E, Shen, J, Kolevzon, A, Buxbaum, JD, Hollander, E, Hof, PR & Fan, J 2011, 'In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism', Brain Research, vol. 1380, pp. 198-205. https://doi.org/10.1016/j.brainres.2010.12.057
Bernardi, Silvia ; Anagnostou, Evdokia ; Shen, Jun ; Kolevzon, Alexander ; Buxbaum, Joseph D. ; Hollander, Eric ; Hof, Patrick R. ; Fan, Jin. / In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism. In: Brain Research. 2011 ; Vol. 1380. pp. 198-205.
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