In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes

Lisa Roux, Eran Stark, Lucas Sjulson, György Buzsáki

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Identification and manipulation of different GABAergic interneuron classes in the behaving animal are important to understand their role in circuit dynamics and behavior. The combination of optogenetics and large-scale neuronal recordings allows specific interneuron populations to be identified and perturbed for circuit analysis in intact animals. A crucial aspect of this approach is coupling electrophysiological recording with spatially and temporally precise light delivery. Focal multisite illumination of neuronal activators and silencers in predetermined temporal configurations or a closed loop manner opens the door to addressing many novel questions. Recent progress demonstrates the utility and power of this novel technique for interneuron research.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume26
DOIs
StatePublished - Jun 1 2014

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ASJC Scopus subject areas

  • Neuroscience(all)

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