In vivo multiple-mouse imaging at 1.5 T

S. Xu, T. P.F. Gade, C. Matei, K. Zakian, A. A. Alfieri, X. Hu, E. C. Holland, S. Soghomonian, J. Tjuvajev, D. Ballon, J. A. Koutcher

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 μm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalMagnetic Resonance in Medicine
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Keywords

  • Brain tumor
  • Lung tumor
  • Multiple mouse MRI coil
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Xu, S., Gade, T. P. F., Matei, C., Zakian, K., Alfieri, A. A., Hu, X., ... Koutcher, J. A. (2003). In vivo multiple-mouse imaging at 1.5 T. Magnetic Resonance in Medicine, 49(3), 551-557. https://doi.org/10.1002/mrm.10397