In vivo multiple-mouse imaging at 1.5 T

S. Xu, T. P F Gade, C. Matei, K. Zakian, A. A. Alfieri, X. Hu, E. C. Holland, S. Soghomonian, J. Tjuvajev, D. Ballon, J. A. Koutcher

Research output: Contribution to journalArticle

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Abstract

A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 μm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalMagnetic Resonance in Medicine
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2003

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Brain Neoplasms
Neoplasms
Magnets
Heterografts
Knockout Mice
Transgenic Mice
Software
Lung

Keywords

  • Brain tumor
  • Lung tumor
  • Multiple mouse MRI coil
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Xu, S., Gade, T. P. F., Matei, C., Zakian, K., Alfieri, A. A., Hu, X., ... Koutcher, J. A. (2003). In vivo multiple-mouse imaging at 1.5 T. Magnetic Resonance in Medicine, 49(3), 551-557. https://doi.org/10.1002/mrm.10397

In vivo multiple-mouse imaging at 1.5 T. / Xu, S.; Gade, T. P F; Matei, C.; Zakian, K.; Alfieri, A. A.; Hu, X.; Holland, E. C.; Soghomonian, S.; Tjuvajev, J.; Ballon, D.; Koutcher, J. A.

In: Magnetic Resonance in Medicine, Vol. 49, No. 3, 01.03.2003, p. 551-557.

Research output: Contribution to journalArticle

Xu, S, Gade, TPF, Matei, C, Zakian, K, Alfieri, AA, Hu, X, Holland, EC, Soghomonian, S, Tjuvajev, J, Ballon, D & Koutcher, JA 2003, 'In vivo multiple-mouse imaging at 1.5 T', Magnetic Resonance in Medicine, vol. 49, no. 3, pp. 551-557. https://doi.org/10.1002/mrm.10397
Xu S, Gade TPF, Matei C, Zakian K, Alfieri AA, Hu X et al. In vivo multiple-mouse imaging at 1.5 T. Magnetic Resonance in Medicine. 2003 Mar 1;49(3):551-557. https://doi.org/10.1002/mrm.10397
Xu, S. ; Gade, T. P F ; Matei, C. ; Zakian, K. ; Alfieri, A. A. ; Hu, X. ; Holland, E. C. ; Soghomonian, S. ; Tjuvajev, J. ; Ballon, D. ; Koutcher, J. A. / In vivo multiple-mouse imaging at 1.5 T. In: Magnetic Resonance in Medicine. 2003 ; Vol. 49, No. 3. pp. 551-557.
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