In vivo model to study the biocompatibility of peritoneal dialysis solutions

K. Wieczorowska-Tobis, K. Korybalska, A. Polubinska, M. Radkowski, A. Breborowicz, D. G. Oreopoulos

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

This study was designed to analyze the complex morphologic and functional effects of dialysis solutions on peritoneum in a rat model on chronic peritoneal dialysis. Peritoneal catheters were inserted into 10 male, Wistar rats and the animals were dialyzed twice daily for 4 weeks with 4.25% Dianeal. During the study we observed two opposite effects: healing of the peritoneum after catheter implantation - decreased cell count in dialysate, decreased permeability of the peritoneum to glucose and total protein, increased volume of drained dialysate; and damage to the membrane due to its exposure to peritoneal dialysis solution - increased hyaluronic acid levels in dialysate, a tendency of the peritoneum to thicken when compared to non- dialyzed animals. Our rat model of CAPD may be used for quantitative and qualitative assessment of the effects of peritoneal dialysis solution on the peritoneum during chronic dialysis.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalInternational Journal of Artificial Organs
Volume20
Issue number12
Publication statusPublished - Dec 1 1997

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Keywords

  • Biocompatibility
  • Peritoneal dialysis
  • Rat model

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Wieczorowska-Tobis, K., Korybalska, K., Polubinska, A., Radkowski, M., Breborowicz, A., & Oreopoulos, D. G. (1997). In vivo model to study the biocompatibility of peritoneal dialysis solutions. International Journal of Artificial Organs, 20(12), 673-677.