In vivo cocaine experience generates silent synapses.

Yanhua H. Huang, Ying Lin, Ping Mu, Brian R. Lee, Travis E. Brown, Gary Wayman, Helene Marie, Wenhua Liu, Zhen Yan, Barbara A. Sorg, Oliver M. Schlüter, R. Suzanne Zukin, Yan Dong

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region mediating addiction-related learning and memory. Furthermore, this cocaine-induced generation of silent synapses is mediated by membrane insertions of new, NR2B-containing N-methyl-D-aspartic acid receptors (NMDARs). These results provide evidence that silent synapses can be generated de novo by in vivo experience and thus may act as highly efficient neural substrates for the subsequent experience-dependent synaptic plasticity underlying extremely long-lasting memory.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalNeuron
Volume63
Issue number1
StatePublished - Jul 16 2009
Externally publishedYes

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Cocaine
Synapses
Neuronal Plasticity
Nucleus Accumbens
Brain
N-Methylaspartate
Learning
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G., ... Dong, Y. (2009). In vivo cocaine experience generates silent synapses. Neuron, 63(1), 40-47.

In vivo cocaine experience generates silent synapses. / Huang, Yanhua H.; Lin, Ying; Mu, Ping; Lee, Brian R.; Brown, Travis E.; Wayman, Gary; Marie, Helene; Liu, Wenhua; Yan, Zhen; Sorg, Barbara A.; Schlüter, Oliver M.; Zukin, R. Suzanne; Dong, Yan.

In: Neuron, Vol. 63, No. 1, 16.07.2009, p. 40-47.

Research output: Contribution to journalArticle

Huang, YH, Lin, Y, Mu, P, Lee, BR, Brown, TE, Wayman, G, Marie, H, Liu, W, Yan, Z, Sorg, BA, Schlüter, OM, Zukin, RS & Dong, Y 2009, 'In vivo cocaine experience generates silent synapses.', Neuron, vol. 63, no. 1, pp. 40-47.
Huang YH, Lin Y, Mu P, Lee BR, Brown TE, Wayman G et al. In vivo cocaine experience generates silent synapses. Neuron. 2009 Jul 16;63(1):40-47.
Huang, Yanhua H. ; Lin, Ying ; Mu, Ping ; Lee, Brian R. ; Brown, Travis E. ; Wayman, Gary ; Marie, Helene ; Liu, Wenhua ; Yan, Zhen ; Sorg, Barbara A. ; Schlüter, Oliver M. ; Zukin, R. Suzanne ; Dong, Yan. / In vivo cocaine experience generates silent synapses. In: Neuron. 2009 ; Vol. 63, No. 1. pp. 40-47.
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